【摘要】：目的合成頭孢羅寧。方法 7-ACA與異煙酰胺反應(yīng)得到7-氨基-3-[(4-氨基甲酰吡啶-1-基)甲基]-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-2-羧酸(簡(jiǎn)寫:7-PACA),再與2-噻吩乙酰氯反應(yīng)得到終產(chǎn)物頭孢羅寧。結(jié)果總收率23.4%,產(chǎn)品質(zhì)量符合英國(guó)藥典(獸藥)標(biāo)準(zhǔn)。結(jié)論本工藝易操作,為中試生產(chǎn)提供了依據(jù)。
[Abstract]:Objective to synthesize cefronin. Methods 7-amino-3- [(4-carbamylpyridine-1-yl) methyl] -8-oxo-5-thio-1-azobis [4.2.0] octyl-2-ene-2 was obtained by the reaction of 7-ACA with isoniamide. -carboxylic acid (7-PACA), The final product cefronine was obtained by reaction with 2-thiophene acetyl chloride. Results the total yield was 23.4 and the quality of the product was up to the standard of British Pharmacopoeia (Veterinary Medicine). Conclusion this process is easy to operate and provides basis for pilot-scale production.
【作者單位】： 成都大學(xué)四川抗菌素工業(yè)研究所;
【分類號(hào)】：R914.5

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