【摘要】：目的:制備尼古丁羥丙基-β-環(huán)糊精(HP-β-CD)包合物,并進(jìn)行包合物的穩(wěn)定性考察。方法:采用冷凍干燥法制備尼古丁的包合物,通過星點設(shè)計-效應(yīng)面法優(yōu)化制備工藝,并做了熱穩(wěn)定性初步考察。結(jié)果:最佳的包合工藝為HP-β-CD與尼古丁物料摩爾比為3.36∶1,包合溫度45℃,包合時間3.5 h,水與HP-β-CD摩爾比為20∶1,平均包合率為56.22%,與預(yù)測值吻合。尼古丁采用環(huán)糊精包合后穩(wěn)定性有顯著提升。結(jié)論:該模型預(yù)測下的優(yōu)化工藝可行,可作為尼古丁包合物的制備工藝。
[Abstract]:Aim: to prepare the inclusion complex of nicotine hydroxypropyl 尾-cyclodextrin (HP- 尾-CD) and investigate its stability. Methods: the inclusion compound of nicotine was prepared by freeze-drying method. The preparation process was optimized by star design-effect surface method, and the thermal stability was investigated. Results: the optimum inclusion conditions were as follows: the molar ratio of HP- 尾-CD to nicotine was 3.36: 1, the inclusion temperature was 45 鈩，

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