【摘要】：目的了解植物化學物芒果苷亞急性毒性作用,確保芒果苷食用安全性。方法成熟健康的清潔級Wistar大鼠80只隨機分為低、中、高劑量芒果苷組(2.75、5.50、11.00 g/kg)和對照組,每組雌雄各10只,連續(xù)喂養(yǎng)30 d,觀察大鼠一般狀態(tài)、稱量體重并計算食物利用率;采用全自動生化分析儀檢測血液學及血液生化學各項指標;觀察主要臟器外觀及病理學改變。結(jié)果對照組及芒果苷各劑量組大鼠生長發(fā)育狀態(tài)良好、飲食飲水正常,活動自如,無死亡;雄性對照組、低、中、高劑量芒果苷組大鼠體重分別為(280.6±18.82)、(279.3±15.55)、(279.8±11.73)、(276.7±19.94)g,體重增長分別為(189.5±17.90)、(188.7±16.69)、(189.2±11.73)、(185.9±17.55)g,食物利用率分別為(28.1±3.07)、(28.6±2.37)、(27.9±0.60)、(27.3±1.92)%;雌性對照組、低、中、高劑量芒果苷組大鼠體重分別為(202.4±12.26)、(204.6±17.20)、(202.1±15.12)、(201.3±12.30)g,體重增長分別為(120.5±14.50)、(121.9±17.50)、(120.2±18.24)、(121.5±15.70)g,食物利用率分別為(22.4±2.60)、(20.5±8.76)、(20.9±2.14)、(21.8±1.64)%;與對照組比較,各劑量芒果苷組大鼠體重、體重增重及食物利用率無明顯變化;與對照組比較,各劑量芒果苷組大鼠血常規(guī)、血液生化學等指標及各主要臟器系數(shù)無明顯變化;高劑量芒果苷組大鼠肝、脾、腎、睪丸、卵巢組織結(jié)構未見病理性改變。結(jié)論以11.00 g/kg劑量芒果苷喂飼大鼠30 d,對大鼠生長發(fā)育及主要臟器無毒性作用。
[Abstract]:Objective to investigate the subacute toxicity of plant chemicals mangiferin and to ensure the edible safety of mangiferin. Methods 80 mature and healthy clean grade Wistar rats were randomly divided into low, medium and high dose mangiferin group (2.75g 5.50 鹵11.00 g/kg) and control group. 10 rats in each group were fed continuously for 30 days, and the general state of the rats was observed. Weighing weight and calculating food utilization rate; The indexes of hematology and blood biochemistry were detected by automatic biochemical analyzer, and the appearance and pathological changes of main organs were observed. Results the rats in the control group and mangiferin groups had good growth and development, normal diet and drinking water, free movement and no death. In the male control group, the body weight of the rats in the low, medium and high dose mangiferin group was (280.6 鹵18.82), (鹵15.55), (279.8 鹵11.73), (276.7 鹵19.94) g, and the weight gain was (189.5 鹵17.90) g, respectively. (188.7 鹵16.69), (189.2 鹵11.73), (185.9 鹵17.55) g, and the food utilization rate was (28.1 鹵3.07), (28.6 鹵2.37), (27.9 鹵0.60), (27.3 鹵1.92)%; The body weight of female control group, low, middle and high dose mangiferin group was (202.4 鹵12.26), () 204.6 鹵17.20), (202.1 鹵15.12), (201.3 鹵12.30) g, and the weight gain was (120.5 鹵14.50) g, respectively. (121.9 鹵17.50), (, 120.2 鹵18.24), (, 121.5 鹵15.70) g, the food utilization rate was (22.4 鹵2.60), (, 20.5 鹵8.76), (, 20.9 鹵2.14), (, 21.8 鹵1.64)%, respectively. Compared with the control group, there were no significant changes in body weight, body weight gain and food utilization rate in each dose of mangiferin group, but there were no significant changes in blood routine examination, blood biochemistry and main organ coefficients in each dose of mangiferin group compared with the control group. There were no pathological changes in liver, spleen, kidney, testis and ovary in high dose mangiferin group. Conclusion the rats fed with mangiferin at 11.00 g/kg for 30 days had no toxic effects on the growth and development of rats and the main organs.
【作者單位】： 東北林業(yè)大學醫(yī)院;哈爾濱醫(yī)科大學公共衛(wèi)生學院營養(yǎng)與食品衛(wèi)生學教研室;
【基金】：國家自然科學基金(81372997)
【分類號】：R99

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