【摘要】：考察了聚氯乙烯(PVC)輸液器與20種注射液的相容性。以不含增塑劑的聚烯烴熱塑性彈性體(TPE)輸液器為對(duì)照組,將20種注射液按說(shuō)明書配成臨床輸液濃度,分別經(jīng)PVC和TPE輸液器流出。采用HPLC或UV法測(cè)定流出液中的藥物濃度,并與0 h時(shí)比較,同時(shí)比較流經(jīng)輸液器前后的藥物濃度變化。采用HPLC法測(cè)定流出液中的鄰苯二甲酸二-(2-乙基己基)酯(DEHP)。結(jié)果顯示,尼莫地平和卡莫司汀注射液流經(jīng)PVC輸液器時(shí)存在嚴(yán)重的吸附作用;單硝酸異山梨酯、氫化可的松、鹽酸胺碘酮、鹽酸氯丙嗪和氟尿嘧啶注射液流經(jīng)PVC輸液器時(shí)也存在較弱的吸附作用;硝酸甘油和硝酸異山梨酯注射液流經(jīng)PVC輸液器后出現(xiàn)新生成物質(zhì)峰;鹽酸胺碘酮注射液流經(jīng)PVC輸液器后有DEHP溶出。
[Abstract]:The compatibility of PVC (PVC) infusion apparatus with 20 kinds of injection was investigated. In the control group, 20 kinds of polyolefin thermoplastic elastomer (TPE) infusion apparatus without plasticizer were used as control group. The 20 kinds of injection were mixed into clinical infusion concentration according to the instructions, and then flowed out through PVC and TPE infusion devices respectively. The concentration of drugs in effluent was determined by HPLC or UV, and compared with that at 0 h, and the changes of drug concentration before and after transfusion were compared. Determination of di- (2-ethylhexyl) phthalate (DEHP). In effluent by HPLC The results showed that nimodipine and carmostatin had serious adsorption effect on PVC infusion. Isosorbide mononitrate, hydrocortisone, amiodarone hydrochloride, chlorpromazine hydrochloride and fluorouracil injection also have weak adsorption effect on PVC infusion. After the injection of nitroglycerin and isosorbide nitrate flowed through the PVC infusion device, the peak of the new substance was found, and the DEHP of amiodarone hydrochloride injection was dissolved after the infusion of PVC.
【作者單位】： 沈陽(yáng)藥科大學(xué)藥學(xué)院;沈陽(yáng)藥科大學(xué)中藥學(xué)院;
【基金】：遼寧省科學(xué)事業(yè)研究公益基金資助項(xiàng)目(2012002010) 遼寧省教育廳創(chuàng)新團(tuán)隊(duì)項(xiàng)目(LT2012018)
【分類號(hào)】：R969

【參考文獻(xiàn)】

中國(guó)期刊全文數(shù)據(jù)庫(kù) 前10條

1 賈芳;李慧勇;王繼才;席紹峰;譚建華;趙田甜;;食品包裝用PVC瓶蓋墊片中增塑劑DEHP的遷移研究[J];包裝工程;2011年01期

2 敖薪;丁勇;黃先菊;;輸液器對(duì)酚妥拉明吸附作用的實(shí)驗(yàn)研究[J];護(hù)理學(xué)雜志;2006年09期

3 祁金文,馬珂,金戈,胡柳青;微泵給藥時(shí)輸液器對(duì)尼莫地平注射液的吸附作用[J];中國(guó)現(xiàn)代應(yīng)用藥學(xué);2003年05期

4 辛鳳鮮;薛云燕;;TPE輸液器藥物相容性探討[J];中國(guó)醫(yī)療器械信息;2011年02期

5 張恩娟,劉同華,江敏,郄學(xué)偉;輸液用塑料制品對(duì)藥物的吸附[J];中國(guó)藥房;2003年11期

6 張恩娟;陳琳;黃林清;;PVC與TPE輸液器對(duì)3種藥物的吸附研究[J];中國(guó)藥房;2007年07期

7 徐小薇,杜小莉,李大魁,樊登峰,張偉琪;3種不同材質(zhì)輸液容器對(duì)15種藥物的吸著性實(shí)驗(yàn)[J];中國(guó)藥學(xué)雜志;2004年03期

8 孫麗麗;魯紅;徐小薇;孫路路;李大魁;;3種不同材質(zhì)輸液容器對(duì)15種藥物的吸著性研究[J];中國(guó)藥學(xué)雜志;2007年02期

9 黃義昆;馬善祥;;聚氯乙烯、聚丙烯和玻璃3種輸液包裝材料對(duì)5種藥物吸附性考察[J];中國(guó)藥師;2007年10期

10 謝新藝;方e，

本文編號(hào)：2305411