【摘要】：通過對利奈唑胺樣品的有關物質分析,并通過制備色譜法分離得到一化合物,測定了其MS、NMR,確認其結構為無氟利奈唑胺。用設計的合成路線得到純度為95.52%的無氟利奈唑胺。合成得到的無氟利奈唑胺可作為利奈唑胺原料藥質量控制的雜質對照品。
[Abstract]:Based on the analysis of the related substances of the sample of linazolamide, a compound was isolated by preparative chromatography, and its structure was confirmed by MS,NMR,. The purity of the product was 95.52%, and the purity was 95.52%. The synthesized non-fluronazolidomide can be used as an impurity reference substance for the quality control of linazolamide.
【作者單位】： 成都大學四川抗菌素工業(yè)研究所;
【基金】：成都大學校基金項目(No.2014XQCKS04)
【分類號】：R914

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