【摘要】：目的應(yīng)用不同親水性載體材料制備聯(lián)苯雙酯固體分散體,提高聯(lián)苯雙酯體外溶出。方法應(yīng)用溶解度參數(shù)法初步篩選載體材料,采用熱熔擠出法制備聯(lián)苯雙酯固體分散體,采用差示掃描量熱法、X射線粉末衍射法和傅立葉變換紅外光譜法對所制備的固體分散體進(jìn)行表征。對固體分散體進(jìn)行溶出度測定,以體外累積溶出度為主要指標(biāo),分別考察不同載體、不同載藥量對固體分散體中聯(lián)苯雙酯溶出度的影響。結(jié)果應(yīng)用不同親水性載體材料制備的固體分散體均可提高聯(lián)苯雙酯溶出度,其中以Soluplus汶對聯(lián)苯雙酯溶出度的提高最為顯著,累積溶出度可達(dá)到90%左右。優(yōu)選Soluplus汶為固體分散體載體材料,并且當(dāng)載藥量為20%時(shí),溶出度最高。結(jié)論應(yīng)用載體材料Soluplus汶制備固體分散體可以顯著提高聯(lián)苯雙酯溶出度。載體材料的性質(zhì)及載藥量的高低都會(huì)影響固體分散體中藥物的溶出度。
[Abstract]:Objective to prepare biphenyl diester solid dispersion with different hydrophilic carrier materials and improve the dissolution of biphenyl diester in vitro. Methods the solid dispersion of biphenyl diester was prepared by hot melt extrusion method by preliminary screening of carrier material by solubility parameter method. The solid dispersion was characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The dissolution of solid dispersions was determined, and the effects of different carriers and drug loading on the dissolution of biphenyl diesters in solid dispersions were investigated with the cumulant dissolution in vitro as the main index. Results the dissolution of biphenyl diesters was improved by using solid dispersions prepared with different hydrophilic carrier materials. The dissolution of biphenyl diesters was increased most significantly by Soluplus, and the cumulative dissolution rate was about 90%. Soluplus was selected as solid dispersion carrier, and the dissolution was the highest when the drug loading was 20. Conclusion the dissolution of biphenyl diester can be significantly improved by the preparation of solid dispersion with Soluplus-bun as carrier material. The properties of carrier materials and the amount of drug loaded will affect the dissolution of drugs in solid dispersions.
【作者單位】： 沈陽藥科大學(xué)藥學(xué)院;
【分類號(hào)】：R943

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