【摘要】：腫瘤抑制因子p73可轉(zhuǎn)錄形成具有促凋亡(TAp73)和抗凋亡(△Np73)功能的2種亞型。但是,在腫瘤進(jìn)程中,TAp73-負(fù)調(diào)節(jié)因子(如△Np73、突變p53、MDM2和iASPP)復(fù)合體的形成會(huì)阻礙TAp73的腫瘤抑制活性。因此,通過(guò)靶向抑制負(fù)調(diào)節(jié)因子或破壞TAp73-負(fù)調(diào)節(jié)因子復(fù)合體,釋放出TAp73,進(jìn)而達(dá)到抑制腫瘤的目的。該文就p73的靶向調(diào)控及相關(guān)藥物的研究進(jìn)展進(jìn)行綜述。
[Abstract]:Tumor suppressor p73 can be transcribed into two subtypes with the function of promoting apoptosis (TAp73) and anti apoptosis (Np73). However, the formation of TAp73- negative regulatory factor complexes (such as Np73, mutation p53 MDM2 and iASPP) in tumor progression may hinder the tumor inhibitory activity of TAp73. Therefore, TAp73, can be released by targeting negative regulatory factor or destroying TAp73- negative regulatory factor complex. In this paper, the target regulation of p73 and the research progress of related drugs are reviewed.
【作者單位】： 昆明理工大學(xué)醫(yī)學(xué)院衰老與腫瘤分子遺傳學(xué)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No 81560601) 昆明理工大學(xué)分析測(cè)試基金項(xiàng)目(No 2016M2014236022)
【分類號(hào)】：R979.1
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本文編號(hào)：2229910