【摘要】：目的:制備大蒜素-羥丙基(HP)-β-環(huán)糊精(CD)包合物滴鼻液并對(duì)其工藝進(jìn)行優(yōu)化。方法:以HP-β-CD對(duì)大蒜素進(jìn)行包合,以包合物收率、滴鼻液中大蒜素含量為綜合評(píng)價(jià)指標(biāo),采用星點(diǎn)設(shè)計(jì)-效應(yīng)面法對(duì)大蒜素滴鼻液的工藝進(jìn)行優(yōu)化,考察HP-β-CD與大蒜素比例、包合溫度、包合時(shí)間等因素的影響,并對(duì)大蒜素包合物進(jìn)行紅外、紫外和顯微鑒別。結(jié)果:大蒜素滴鼻液的最佳制備工藝為:以水為包合溶媒,HP-β-環(huán)糊精和大蒜素的比例為32∶1,攪拌速度200 r·min-1,包合溫度35℃,包合時(shí)間1.5 h。在此條件下,大蒜素的包合率達(dá)到90.25%。紅外、紫外和顯微鑒別結(jié)果均表明,大蒜素以包合物形式存在于滴鼻液中。結(jié)論:采用星點(diǎn)設(shè)計(jì)-效應(yīng)面法優(yōu)化所得大蒜素HP-β-CD包合物滴鼻液的制備工藝合理可行,為大蒜素液體制劑的進(jìn)一步開發(fā)奠定了基礎(chǔ)。
[Abstract]:Aim: to prepare allicin-hydroxypropyl (HP)-尾-cyclodextrin (CD) inclusion compound nasal drops and optimize its technology. Methods: allicin was encapsulated with HP- 尾 -CD, the yield of inclusion compound and the content of allicin in nasal drops were used as the comprehensive evaluation index. The technology of allicin nasal drops was optimized by star design-effect surface method, and the ratio of HP- 尾 -CD to allicin was investigated. Inclusion temperature, inclusion time and other factors, and the inclusion of allicin by infrared, UV and microscopic identification. Results: the optimum preparation technology of allicin nasal drops was as follows: the ratio of H P- 尾 -cyclodextrin and allicin in water was 32: 1, the stirring rate was 200r min-1, and the inclusion temperature was 35 鈩，

本文編號(hào)：2221603