【摘要】：目的近幾十年,肌肉型乙酰膽堿受體(nicotinic acetylcholine receptors,nAChRs)成為神經(jīng)生理學(xué)、藥理學(xué)、藥物設(shè)計(jì)及相關(guān)疾病研究的重要靶點(diǎn)。包括橫紋肌肉瘤、小兒軟組織瘤、肌源性紊亂等疾病都與肌肉型nAChRs的異常有關(guān)。因此尋找針對(duì)肌肉型nAChRs的特異性探針,對(duì)于研究受體的結(jié)構(gòu)、功能及相關(guān)疾病發(fā)病機(jī)理與治療藥物研發(fā)至關(guān)重要。方法通過(guò)查閱相關(guān)文獻(xiàn)對(duì)近年來(lái)發(fā)現(xiàn)的特異作用于肌肉型nAChRs的生物毒素進(jìn)行了綜述。結(jié)果與結(jié)論自然界中存在許多天然生物毒素,能特異作用于肌肉型nAChRs,這些毒素對(duì)于研究肌肉型nAChRs的結(jié)構(gòu)和功能,以及相關(guān)疾病的診斷和治療有著非常重要的應(yīng)用價(jià)值。
[Abstract]:Objective in recent decades, muscle-type acetylcholine receptor (nicotinic acetylcholine receptor) has become an important target in neurophysiology, drug design and related diseases. Disorders such as rhabdomyosarcoma, soft tissue tumors in children, and myogenic disorders are all associated with abnormal muscular nAChRs. Therefore, it is very important to search for specific probes for muscle-type nAChRs in order to study the structure, function, pathogenesis of related diseases and the development of therapeutic drugs. Methods the biotoxins specific to muscular nAChRs were reviewed in recent years. Results and conclusion there are many natural biotoxins in nature, which can act specifically on muscle-type nAChRs. These toxins are of great value in the study of the structure and function of muscle-type nAChRs and in the diagnosis and treatment of related diseases.
【作者單位】： 海南大學(xué)熱帶生物資源教育部重點(diǎn)實(shí)驗(yàn)室海口市海洋藥物重點(diǎn)實(shí)驗(yàn)室;海南大學(xué)農(nóng)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(41366002) 長(zhǎng)江學(xué)者和創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃資助項(xiàng)目(IRT_15R15)
【分類(lèi)號(hào)】：R96

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