【摘要】：伊曲康唑難溶于水,使其用藥方式受到限制.以多聚物5k PEGCA8作為包裹物,采用薄膜分散法制備伊曲康唑納米粒,靜脈注射小鼠體內(nèi),采用熒光-HPLC測定血液和體內(nèi)組織中伊曲康唑藥物濃度,并通過藥代動力學軟件Win Nonlin測定納米粒型伊曲康唑在小鼠體內(nèi)的藥代動力學特性.結(jié)果表明:小鼠血液最大濃度Cmax為(2.850±0.075)μg/L,血藥濃度-時間曲線下面積AUC(0-∞)為(25 490.84±720.416)(μg·h)/L,半衰期t1/2z為(6.526±1.386)h,達鋒時間Tmax為1h.研究結(jié)果表明,納米型伊曲康唑可以有效解決伊曲康唑難溶于水的問題,為伊曲康唑注射針劑的開發(fā)提供了參考.
[Abstract]:Itraconazole is insoluble in water, limiting its drug use. Itraconazole nanoparticles were prepared by thin-film dispersion method with polymer 5k PEGCA8. The concentrations of itraconazole in blood and tissue were determined by fluorescence HPLC. The pharmacokinetics of itraconazole nanoparticles in mice was determined by pharmacokinetic software Win Nonlin. The results showed that the maximum blood concentration (Cmax) of mice was (2.850 鹵0.075) 渭 g / L, the area under the plasma concentration-time curve (AUC _ 鈭，

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