【摘要】：慢性腎臟病(chronic kidney disease,CKD)是一種長(zhǎng)期性進(jìn)展性疾病,是以腎功能丟失逐漸加重為特征的一種疾病,甚至?xí)䦟?dǎo)致終末期腎臟疾病,需要腎移植或者腎透析。貧血是CKD患者的常見(jiàn)并發(fā)癥,且隨腎功能下降貧血發(fā)生率不斷上升。紅細(xì)胞生成刺激劑(erythropoiesis stimulating agents,ESAs)是目前治療腎性貧血的主導(dǎo)藥物,然而,心血管安全風(fēng)險(xiǎn)限制了ESAs的應(yīng)用。所以,近幾年開(kāi)始探索新型的紅細(xì)胞生成刺激劑制劑,一種新型口服的低氧誘導(dǎo)因子脯氨酰羥化酶(hypoxia-inducible factor-prolyl hydroxylase,HIF-PHD)抑制劑,日益受到國(guó)內(nèi)外研究人員的關(guān)注,然而系統(tǒng)的綜述較少。鑒于此,本文將對(duì)新型的口服低氧誘導(dǎo)因子脯氨酰羥化酶抑制劑的作用機(jī)制及全球研究進(jìn)展進(jìn)行綜述,重點(diǎn)對(duì)目前研發(fā)比較成熟進(jìn)入臨床階段的藥物進(jìn)行綜述。
[Abstract]:Chronic kidney disease (chronic kidney) is a long-term progressive disease characterized by gradual deterioration of renal function. It may even lead to end-stage renal disease requiring kidney transplantation or renal dialysis. Anemia is a common complication in patients with CKD, and the incidence of anemia increases with the decline of renal function. ESAs, a erythrocyte stimulating agent, is the leading drug in the treatment of renal anemia. However, cardiovascular safety risks limit the use of ESAs. Therefore, in recent years, researchers at home and abroad have been paying more and more attention to a new erythrocyte stimulating agent, a new type of hypoxia-inducible factor-prolyl hydroxylase HIF-PhD inhibitor, which has been systematically reviewed. In view of this, this article will review the action mechanism and global research progress of new oral hypoxia inducible factor proline hydroxylase inhibitors, focusing on the current research and development of more mature drugs into the clinical stage.
【作者單位】： 江蘇德源藥業(yè)股份有限公司;
【分類號(hào)】：R969.4

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