【摘要】：新藥創(chuàng)制是復(fù)雜的智力活動,涉及科學(xué)研究、技術(shù)創(chuàng)造、產(chǎn)品開發(fā)和醫(yī)療效果等多維科技活動。每個藥物都有自身的研發(fā)軌跡,而構(gòu)建化學(xué)結(jié)構(gòu)是最重要的環(huán)節(jié),因為它涵蓋了藥效、藥代、安全性和生物藥劑學(xué)等性質(zhì)。本欄目以藥物化學(xué)視角,對有代表性的藥物的成功構(gòu)建,加以剖析和解讀。在現(xiàn)代藥物研發(fā)史上阿托伐他汀占有重要一頁。作為安全有效的降脂、心血管保護藥,曾是多年的銷售額全球第一的重磅藥物,年銷售過百億美元。然而阿托伐他汀的研制并非首創(chuàng),而是個跟隨性的、全球第五個上市的他汀藥物,它以后來居上的姿態(tài)雄踞鰲頭,雖然有一定商業(yè)運作因素,但主要是其品質(zhì)優(yōu)良。本文簡要介紹了阿托伐他汀研發(fā)的藥物化學(xué)過程。
[Abstract]:New drug creation is a complex intellectual activity involving multi-dimensional scientific and technological activities such as scientific research, technological creation, product development and medical effects. Each drug has its own R & D track, and the construction of chemical structures is the most important step because it covers pharmacodynamics, pharmacology, safety and biopharmaceutical properties. This column analyzes and interprets the successful construction of representative drugs from the perspective of drug chemistry. Atto vastatin plays an important role in the history of modern drug development. As a safe and effective lipid-lowering and cardiovascular protection drug, it has been the world's largest drug in sales for many years, with annual sales of more than $10 billion. However, the development of Atto vastatin is not the first, but a follow, the fifth on the market statins in the world, it takes the leading position with a backward attitude, although there are certain commercial factors, but mainly because of its good quality. In this paper, the pharmacochemical process of Atto vastatin was briefly introduced.
【作者單位】： 中國醫(yī)學(xué)科學(xué)院 北京協(xié)和醫(yī)學(xué)院藥物研究所;
【分類號】：R972.6
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本文編號：2143772