發(fā)布時間：2018-07-24 17:28

【摘要】：目的探討單次灌胃給予莫西沙星大鼠的組織分布及藥代動力學(xué)。方法 60只SD大鼠分為10組,按莫西沙星50mg/kg灌胃給藥,給藥前及給藥后0.25、0.50、1.00、2.00、3.00、4.00、6.00、8.00、12.00、24.00h分別取肺、子宮、卵巢輸卵管、腎臟、輸尿管及膀胱組織,高效液相色譜法(HPLC)測定各組織中莫西沙星的藥物濃度,3p97軟件擬合藥代動力學(xué)參數(shù)。結(jié)果建立HPLC測定組織中莫西沙星藥物濃度的方法,專屬性好,藥物濃度在0.001 6~50.000 0μg/mL線性關(guān)系良好。給藥后肺、子宮、卵巢輸卵管、腎臟、輸尿管及膀胱組織T1/2β分別為(13.65±3.56)h、(12.64±2.86)h、(13.27±3.51)h、(13.47±3.29)h、(14.78±2.64)h及(11.56±1.58)h,Cmax分別為(15.61±3.58)μg/mL、(12.48±4.57)μg/mL、(16.18±4.21)μg/mL、(12.65±3.17)μg/mL、(26.68±7.42)μg/mL和(1.13±0.58)μg/mL,Tmax分別為(3.15±1.24)h、(2.66±1.74)h、(2.97±1.65)h、(2.58±1.36)h、(3.47±1.84)h和(2.46±1.87)h,AUC0~t分別為(87.2±5.41)μg·h-1·mL-1、(70.89±4.56)μg·h-1·mL-1、(92.41±7.65)μg·h-1·mL-1、(88.26±6.94)μg·h-1·mL-1、(170.59±21.48)μg·h-1·mL-1和(14.57±5.47)μg·h-1·mL-1。結(jié)論大鼠單劑量灌服莫西沙星后輸尿管和卵巢輸卵管組織有較高的藥物濃度,可維持較長時間。
[Abstract]:Objective to investigate the tissue distribution and pharmacokinetics of moxifloxacin in rats. Methods Sixty Sprague-Dawley rats were divided into 10 groups. The lung, uterus, ovary, kidney, ureter and bladder were collected before and after administration of moxifloxacin 50mg/kg. The pharmacokinetic parameters of moxifloxacin in tissues were determined by (HPLC) with 3p97 software. Results A HPLC method was established for the determination of moxifloxacin in tissues. The specificity of the method was good. The linear relationship between the concentration of moxifloxacin and moxifloxacin was 0.001 ~ 50.000 渭 g/mL. 緇欒嵂鍚庤偤,瀛愬,鍗靛發(fā)杈撳嵉綆，

本文編號：2142114