【摘要】：目的研究注射用頭孢拉宗在中國健康人體的藥代動力學。方法用開放、隨機、自身三交叉對照試驗設計。12名受試者分別接受單次靜脈滴注頭孢拉宗1.0,2.0,3.0 g,通過高效液相色譜法測定頭孢拉宗濃度。用WinNonlin5.2.1計算藥代動力學參數。結果頭孢拉宗的線性范圍為2~250μg·mL~(-1),頭孢拉宗1.0,2.0,3.0 g的主要藥代動學參數:C_(max)分別為(81.74±15.95),(145.47±42.22),(198.16±36.03)μg·mL~(-1),t_(max)分別為(1.01±0.03),(1.02±0.04),(1.01±0.03)h;t_(1/2)分別為(1.80±0.30),(1.88±0.31),(1.74±0.27)h;AUC_(0-t)分別為(136.37±43.31),(263.74±93.95),(335.76±68.47)μg·mL~(-1)·h。16 h后的尿藥累積排泄率分別為(45.24±17.50)%,(48.27±15.18)%,(40.82±14.24)%。結論受試者單次靜脈滴注頭孢拉宗1.0,2.0,3.0 g后藥物體內過程呈一級線性動力學特征。
[Abstract]:Objective to study the pharmacokinetics of cefradine for injection in Chinese healthy volunteers. Methods Cefradazon concentration was determined by high performance liquid chromatography (HPLC) in 12 subjects who received a single intravenous drip of cefradazone 1.0 ~ 2.0 ~ 3.0 g in an open, randomized, self-controlled triple-controlled trial. The pharmacokinetic parameters were calculated with WinNonlin 5.2.1. 緇撴灉澶村鎷夊畻鐨勭嚎鎬ц寖鍥翠負2~250渭g路mL~(-1),澶村鎷夊畻1.0,2.0,3.0 g鐨勪富瑕佽嵂浠ｅ姩瀛﹀弬鏁，

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