本文選題：氫溴酸高烏甲素 + 納米粒��； 參考：《中成藥》2017年05期

【摘要】：目的制備氫溴酸高烏甲素納米粒緩釋片。方法高壓乳勻法制備納米粒,真空冷凍干燥后,將其與骨架緩釋片輔料混勻,制備緩釋凝膠骨架片。通過單因素試驗(yàn)考察吸附劑種類、羥丙基甲基纖維素(HPMC)類型及其用量、聚乙二醇(PEG)類型對(duì)釋藥行為的影響。結(jié)果最佳條件為以乳糖為吸附劑,HPMC 4K和HPMC 15M(比例1∶1)用量40 mg/片,PEG 400與PEG4000比例2∶1,所得緩釋片的體外釋放符合零級(jí)釋藥模型,12 h累積釋放度達(dá)89.82%。結(jié)論該方法簡單可靠,有利于工業(yè)化大批量生產(chǎn)氫溴酸高烏甲素納米粒緩釋片。
[Abstract]:Objective to prepare sustained release tablets of rapeconitine hydrobromide nanoparticles. Methods Nano-particles were prepared by high pressure emulsion method. After freeze-drying in vacuum, they were mixed with skeleton sustained-release tablets to prepare sustained-release gel matrix tablets. The effects of kinds of adsorbents, types and dosage of hydroxypropyl methyl cellulose (HPMC) and polyethylene glycol (PEG) on drug release behavior were investigated by single factor test. Results the optimum conditions were as follows: using lactose as adsorbent HPMC4K and HPMC15M (1:1), the ratio of PEG400 to PEG4000 was 2: 1. The release rate of the tablets in vitro was up to 89.82% in accordance with the zero-order drug release model. Conclusion the method is simple and reliable, which is beneficial to the production of buconiconitine hydrobromide nanocrystalline sustained release tablets.
【作者單位】： 鄭州澍青醫(yī)學(xué)高等�？茖W(xué)校;中國醫(yī)藥工業(yè)研究總院上海醫(yī)藥工業(yè)研究院;
【分類號(hào)】：R943

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