本文選題：美索巴莫磷酸鈉 + 驚厥　； 參考：《中國臨床藥理學雜志》2017年01期

【摘要】：目的研究美索巴莫磷酸鈉對小鼠的抗驚厥作用及肌肉松弛作用。方法將小鼠按照體重隨機分組,每組10只,雌雄各半,將美索巴莫磷酸鈉(Me-Na)制備成質(zhì)量分數(shù)為231,462,924,1848 mg·kg~(-1)的系列溶液,采用灌胃(給藥后30 min實驗)和注射(給藥后10 min實驗)兩種途徑給予小鼠,并與美索巴莫(650 mg·kg~(-1))作用效果對比�？贵@厥實驗:分別研究不同濃度美索巴莫磷酸鈉抗電驚厥及抗士的寧驚厥作用,給藥后記錄小鼠的驚厥發(fā)生率和驚厥出現(xiàn)時間,研究其抗驚厥效果。肌肉松弛實驗:給藥后通過檢測小鼠的抓力和轉(zhuǎn)桿時間,研究美索巴莫磷酸鈉對小鼠的肌肉松弛作用。結(jié)果抗電驚厥實驗:灌胃組中的空白組、對照組、實驗Ⅱ、Ⅲ、Ⅳ組發(fā)生例數(shù)為10,0,6,4,0例;注射組中的空白組、對照組、實驗Ⅲ組發(fā)生例數(shù)為10,3,5例,與空白組相比,對照組和實驗組的差異有統(tǒng)計學意義(P0.05)。抗士的寧驚厥實驗:灌胃組中的空白組和實驗Ⅱ組驚厥出現(xiàn)的時間為(8.89±1.69),(14.60±3.81)min,注射組中的空白組、對照組和實驗Ⅰ、Ⅱ、Ⅲ組驚厥出現(xiàn)的時間為(6.44±1.86),(12.31±2.34),(19.88±3.79),(12.73±1.72),(13.22±1.67)min,與空白組相比,對照組和實驗組的差異有統(tǒng)計學意義(P0.01)。抓力實驗:灌胃組中的空白組、對照組和實驗Ⅱ、Ⅲ、Ⅳ組的抓力與體重的比值分別為(6.44±0.54),(3.14±0.97),(4.18±1.31),(3.51±1.65),(2.93±1.06)N·g~(-1),注射組中的空白組、對照組和實驗Ⅰ、Ⅱ、Ⅲ組的抓力與體重的比值為(6.67±0.69),(1.54±0.33),(2.84±0.53),(3.83±0.92),(3.22±1.09)N·g~(-1),與空白組相比,對照組和實驗組的差異有統(tǒng)計學意義(P0.01)。轉(zhuǎn)桿實驗:灌胃組中的空白組、對照組和實驗Ⅲ、Ⅳ組的轉(zhuǎn)桿持續(xù)時間為(175.24±7.08),(5.96±4.84),(10.83±6.27),(3.73±1.66)s,注射組中的空白組、對照組和實驗Ⅱ、Ⅲ組轉(zhuǎn)桿持續(xù)時間為(174.71±7.29),(2.33±0.58),(7.06±4.45),(1.56±0.62)s,與空白組相比,對照組和實驗組的差異有統(tǒng)計學意義(P0.001)。結(jié)論美索巴莫磷酸鈉對小鼠具有抗驚厥作用和肌肉松弛作用,且與臨床應(yīng)用的美索巴莫效果相當。
[Abstract]:Objective to study the anticonvulsant and muscle relaxation effects of sodium mesophosphate on mice. Methods mice were randomly divided according to their body weight, 10 mice in each group, half male and half female. A series of solutions with mass fraction of 231462U 924m 1848 mg 路kg ~ (-1) were prepared from Me-Na. Mice were given intragastric administration (30 min after administration) and injection (10 min after administration), and the effects were compared with that of misobutamol (650 mg / kg). Anticonvulsant experiment: the anticonvulsant and anticonvulsant effects of different concentrations of sodium mesophosphate were studied respectively. The incidence and time of convulsion in mice were recorded after administration, and the anticonvulsant effect was studied. Muscle relaxation test: the muscle relaxation effect of sodium mesophosphate on mice was studied by measuring the grasping force and rotation time of mice after administration. Results in the anticonvulsant experiment, the number of cases in the blank group, control group, experimental group 鈪，

本文編號：2016857