本文選題：藥物濃度 + 峰值濃度��； 參考：《中國醫(yī)院藥學雜志》2015年02期

【摘要】：目的:探索藥物入壺后輸出液藥物濃度峰值變化規(guī)律并分析其影響因素,為臨床規(guī)范應用這一給藥方式提供理論依據。方法:用紫外可見光光度儀連續(xù)監(jiān)測龍膽紫飽和溶液入壺后輸出液體的吸光度,將測得的吸光度轉換成藥物濃度,獲得輸出液藥物濃度峰值。分別設定輸液速度為90,180,360,720 ml·h-1;輸液器滴壺內液體量分別設定為2,3,4 ml;入壺溶液分別為1,2 ml。對實驗結果進行統(tǒng)計學分析。結果:輸液速度(x1)、滴壺內液體量(x2)、入壺藥量(x3)對輸出液藥物濃度峰值(y)均有影響,差異具有統(tǒng)計學意義(P0.05)。對于3個影響因素的多元線性回歸分析得到^y=7.283+0.003 x1-1.904x2+8.820 x3(R2=0.947,F=547.080),三者影響由大到小依次為:入壺藥量、壺內液量、輸液速度。入壺藥量越大,輸出液藥物濃度峰值越高,壺內液量越多輸出液藥物濃度峰值越低,輸液速度越快輸出液藥物濃度峰值越高。結論:入壺給藥時輸出液藥物濃度受多種因素影響,與靜脈注射藥物濃度變化規(guī)律不同,一些藥物不能采用入壺方式代替靜脈注射。
[Abstract]:Objective: to explore the change rule of the peak concentration of the drug in the exported solution after the medicine was put into the pot and analyze its influencing factors, and to provide the theoretical basis for the clinical standard application of the drug. Methods: UV-vis spectrophotometer was used to continuously monitor the absorbance of the liquid after the saturated solution of Gentian Violet was put into the pot. The absorbance was converted into the drug concentration and the peak value of the drug concentration was obtained. The infusion rate was set at 90180360720 ml h-1, the volume of liquid in the infusion pot was set at 2 ~ 3 ~ 4 ml, and that in the pot was 1 ~ 2 ml. The experimental results were analyzed statistically. Results: the rate of infusion (x 1), the volume of liquid in the pot (x 2) and the amount of medicine in the pot (x 3) all affected the peak value of the drug concentration in the export solution (P 0.05), and the difference was statistically significant (P < 0.05). For the three influencing factors, the multiple linear regression analysis showed that the three influencing factors were 7.283 0.003 x1-1.904x2 8.820 x 3N R2O 0.947 FN 547.080, the order of the three effects from big to small was as follows: the quantity of medicine into pot, the quantity of liquid in pot, and the velocity of infusion. The higher the amount of medicine into the pot, the higher the peak value of the drug concentration in the output liquid, the lower the peak value of the drug concentration in the output liquid, the higher the velocity of infusion, the higher the peak value of the drug concentration in the output liquid. Conclusion: the concentration of the exported solution is affected by many factors, which is different from that of intravenous injection. Some drugs can not be used as a substitute for intravenous injection.
【作者單位】： 河北醫(yī)科大學第三醫(yī)院;北京鐵路局石家莊衛(wèi)生防疫站;
【基金】：河北省2010年醫(yī)學科學研究重點課題計劃(20100362)
【分類號】：R969

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