本文選題：藥師 + 抗凝服務(wù)��； 參考：《中國藥學(xué)雜志》2015年06期

【摘要】：目的系統(tǒng)的評(píng)價(jià)藥師參與的抗凝服務(wù)對(duì)華法林治療管理的作用。方法計(jì)算機(jī)檢索OVID、SCI、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(CBM)、中國知網(wǎng)(CNKI)、維普中文期刊數(shù)據(jù)庫(VIP)數(shù)據(jù)庫,萬方數(shù)據(jù)庫(WANFANG),納入藥師參與的抗凝服務(wù)對(duì)華法林治療管理作用的隨機(jī)對(duì)照試驗(yàn),檢索時(shí)間從建庫至2014年1月。系統(tǒng)篩選文獻(xiàn)、提取資料及評(píng)價(jià)質(zhì)量后,采用Rev Man5.0軟件進(jìn)行Meta分析。結(jié)果共納入9個(gè)隨機(jī)對(duì)照試驗(yàn),1 630例患者。Meta分析結(jié)果顯示,試驗(yàn)組與對(duì)照組結(jié)局指標(biāo):精確的國際標(biāo)準(zhǔn)化比值(international normalized ratio,INR)治療目標(biāo)范圍時(shí)間比、寬松的國際標(biāo)準(zhǔn)化比值治療目標(biāo)范圍(目標(biāo)INR±0.2)時(shí)間比、全因死亡率、主要出血事件發(fā)生率、血栓栓塞事件發(fā)生率差異均無統(tǒng)計(jì)學(xué)意義,效應(yīng)量依次為MD=1.24,95%CI(-2.83,5.30),P=0.55;MD=2.86,95%CI(-1.52,7.25),P=0.20;RR=0.87,95%CI(0.40,1.91),P=0.73;RR=0.65,95%CI(0.32,1.34),P=0.24;RR=0.85,95%CI(0.40,1.78),P=0.66。而患者滿意度指標(biāo)顯示患者對(duì)試驗(yàn)組的滿意度高于對(duì)照組(P≤0.001)。結(jié)論基于當(dāng)前證據(jù),除能增加患者滿意度外,藥師參與的抗凝服務(wù)對(duì)華法林治療管理的其他作用仍有待進(jìn)一步的研究支持。
[Abstract]:Objective to evaluate the effect of anticoagulant service on warfarin therapy. Methods A computerized search was conducted for OVID-SCI, Chinese Biomedical Literature Database (CBMN), China knowledge Network (CNKI), Weipu Chinese Journal Database (Vip) and Wanfang database (WANFANGG). The results were collected from a randomized controlled trial of the effect of anticoagulant services on the management of warfarin. The retrieval time was from the construction of the database to January 2014. After systematically sifting literature, extracting data and evaluating quality, Meta analysis was carried out with Rev Man5.0 software. Results A total of 1 630 patients were enrolled in 9 randomized controlled trials. The results of Meta-analysis showed that the outcome index of the trial group and the control group: the precise international normalized ratio- INR ratio. There was no significant difference in the treatment target range (target INR 鹵0.2) of the looser international standardized ratio (target INR 鹵0.2). There was no significant difference in the total mortality rate, the incidence of major haemorrhage events and the incidence of thromboembolism. The order of effect was MD1.2495CI-2.83CI-2.883 ~ (5.30). The patient satisfaction index showed that the patients' satisfaction was higher than that of the control group (P 鈮，

本文編號(hào)：1973828