本文選題：水溶性水飛薊素 + 卡馬西平��； 參考：《中國藥房》2015年01期

【摘要】：目的:研究水溶性水飛薊素對(duì)大鼠體內(nèi)卡馬西平(CBZ)藥動(dòng)學(xué)的影響。方法:取18只大鼠隨機(jī)均分為對(duì)照組(生理氯化鈉溶液)、水溶性水飛薊素普通劑量(50 mg/kg)組、水溶性水飛薊素高劑量(100 mg/kg)組,灌胃給予相應(yīng)藥物,每日1次,連續(xù)給藥7 d,末次給藥1 h后所有大鼠灌胃給予CBZ 50 mg/kg。分別于給藥前及給予CBZ后0.5、1、1.5、2、4、6、8、10、12 h眼眶取血,以地西泮為內(nèi)標(biāo),以高效液相色譜法測定血漿中CBZ及其代謝產(chǎn)物10,11-環(huán)氧卡馬西平(ECBZ)的濃度,并利用Win Nolin 5.2藥動(dòng)學(xué)軟件計(jì)算藥動(dòng)學(xué)參數(shù)。結(jié)果:與對(duì)照組比較,水溶性水飛薊素普通劑量組和水溶性水飛薊素高劑量組大鼠體內(nèi)CBZ的Ka明顯增加[(0.31±0.22)vs.(2.66±3.12)、(5.26±4.58)h-1,P0.05],ECBZ的AUC0-12 h[(53.87±7.31)vs.(70.65±12.79)、(68.44±4.62)mg·h/L,P0.05]、cmax[(7.20±0.87)vs.(8.82±0.54)、(8.19±0.38)mg/L,P0.05]明顯增加,其余藥動(dòng)學(xué)參數(shù)比較差異無統(tǒng)計(jì)學(xué)意義。結(jié)論:水溶性水飛薊素連續(xù)服用可促進(jìn)CBZ在大鼠體內(nèi)的吸收,同時(shí)有促進(jìn)CBZ體內(nèi)代謝的趨勢,臨床上兩者合用時(shí)應(yīng)注意潛在的藥物相互作用。
[Abstract]:Aim: to study the effect of water soluble silymarin on the pharmacokinetics of carbamazepine (CBZ) in rats. Methods: eighteen rats were randomly divided into control group (physiological sodium chloride solution, water soluble silymarin 50 mg / kg) group and water soluble silymarin high dose (100 mg / kg) group. All the rats were given CBZ 50 mg / kg by gavage 1 h after the last administration for 7 days. The concentrations of CBZ and its metabolite 10BZ in plasma were determined by HPLC with diazepam as internal standard before and after administration of CBZ. The pharmacokinetic parameters were calculated by Win Nolin 5.2 pharmacokinetic software. 緇撴灉:涓庡鐓х粍姣旇緝,姘存憾鎬ф按椋炶摕绱犳櫘閫氬墏閲忕粍鍜屾按婧舵，

本文編號(hào)：1973477