本文選題：炔銀 + 硫醇銀　； 參考：《佳木斯大學(xué)》2016年碩士論文

【摘要】：目的通過調(diào)控多金屬氧酸鹽陰離子的種類及尺寸,誘導(dǎo)合成系列納米有機銀簇抗菌劑;探索其抗菌活性,篩選出具有優(yōu)良抗菌性能的抗菌劑。方法利用溶劑熱方法合成系列納米有機銀簇化合物;通過X-射線單晶衍射、紅外光譜、元素分析等方法對化合物進行結(jié)構(gòu)表征。利用熒光光譜研究納米有機銀簇化合物的熒光特性,采用納米無機材料抗菌性能檢測方法研究試驗化合物的抑菌活性。結(jié)果成功的合成出7個基于不同多金屬氧酸鹽模板劑的納米有機銀簇化合物。以發(fā)光型EuW_(10)多酸陰離子作為模板劑,首次合成出具有發(fā)光特性的42核(化合物1)和72核(化合物2)炔銀簇化合物;以偏釩酸銨為模板劑原料,硫醇為有機配體,通過調(diào)節(jié)反應(yīng)體系的pH,在甲醇溶劑中進行自組裝反應(yīng),成功合成了系列硫醇銀納米簇合物(3~7)。其中,化合物4~6是首次在納米尺度上合成出具有柏拉圖模型的正十二面體有機銀簇化合物,也是首例具有酸堿誘導(dǎo)變色的納米銀簇化合物。該類化合物的成功合成不僅為納米銀簇家族添加了新成員,也為對外界刺激有應(yīng)激反應(yīng)的智能型簇合物的研究提供新的結(jié)構(gòu)模型。對大腸桿菌抑菌活性試驗表明,化合物1和2抑菌活性良好,抑菌率分別為95.5%和97.7%�；衔�3~7的抑菌性顯著不同,抑菌率分別為21.4%,70.0%,95.1%,81.6%和59.2%。結(jié)論以叔丁基炔或叔丁基硫醇為有機配體,通過溶劑熱法設(shè)計合成了7個新型納米有機銀簇化合物,研究納米銀簇對大腸桿菌的抑菌性能。抑菌實驗結(jié)果表明,納米有機銀簇化合物的抗菌效果明顯高于前軀體叔丁基炔銀和硫醇銀;另外,納米有機銀簇化合物核心模板劑(多酸陰離子)種類和構(gòu)型,以及銀殼層中銀核數(shù)量和構(gòu)型的不同都會顯著影響化合物對大腸桿菌的抑制作用。該類化合物的成功制備,為有機銀簇在抗菌領(lǐng)域的應(yīng)用提供了基礎(chǔ)數(shù)據(jù)和結(jié)構(gòu)模型。
[Abstract]:Objective to induce the synthesis of a series of nano-organosilver cluster antimicrobial agents by regulating the species and size of polyoxometalate anions, to explore their antibacterial activities and to screen out antimicrobial agents with excellent antibacterial properties. Methods A series of nano-organosilver cluster compounds were synthesized by solvothermal method and characterized by X-ray single crystal diffraction, infrared spectroscopy and elemental analysis. Fluorescence spectra were used to study the fluorescence characteristics of nano-organo silver cluster compounds, and the antibacterial activity of the tested compounds was studied by the method of antimicrobial properties of nano-inorganic materials. Results Seven nanoorganosilver clusters based on different polyoxometalate templates were successfully synthesized. Silver clusters of 42 nuclei (compounds 1) and 72 nuclei (compounds 2) with luminescent properties were synthesized by using the luminescent EuWS 10) polyacid anions as templates, using ammonium metavanadate as template material and mercaptan as organic ligands. A series of silver mercaptan nanoclusters were successfully synthesized by self-assembly reaction in methanol solvent by adjusting the pH of the reaction system. Among them, compound 4N 6 is the first organic dodecahedron silver cluster compound with Plato model on nanometer scale, and it is also the first nano-silver cluster compound with acid-base induced color change. The successful synthesis of these compounds not only adds new members to the silver nanoclusters, but also provides a new structural model for the study of intelligent clusters with external stimuli. The bacteriostatic activity of compounds 1 and 2 was good in Escherichia coli. The bacteriostatic rates of compounds 1 and 2 were 95. 5% and 97. 7%, respectively. The antimicrobial activity of compound 3Y7 was significantly different, the antibacterial rate was 21.40.0and 95.1% and 59.2%, respectively. Conclusion Seven novel nano-organosilver clusters were synthesized by solvothermal method using tert Ding Ji acetylene or tertiary Ding Ji mercaptan as organic ligands, and the bacteriostatic properties of nano-silver clusters against Escherichia coli were studied. The results of bacteriostatic test showed that the antibacterial effect of nano-organo silver cluster compounds was significantly higher than that of tert-tert Ding Ji silver and mercaptan silver, in addition, the types and configurations of core templates (polyacid anions) of nano-organo silver clusters were higher than those of precursor tert-silver clusters. The number and configuration of silver nuclei in the silver shell significantly affected the inhibition of the compounds on Escherichia coli. The successful preparation of this kind of compounds provides the basic data and structural model for the application of organic silver clusters in antibacterial field.
【學(xué)位授予單位】：佳木斯大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R914.5

【參考文獻】

相關(guān)期刊論文 前6條

1 M.Raffi;F.Hussain;T.M.Bhatti;J.I.Akhter;A.Hameed;M.M.Hasan;;Antibacterial Characterization of Silver Nanoparticles against E.Coli ATCC-15224[J];Journal of Materials Science & Technology;2008年02期

2 殷煥順;艾仕云;錢萍;汪建民;;納米銀的制備方法及其應(yīng)用[J];材料研究與應(yīng)用;2008年01期

3 馬楠;季君暉;崔德健;熊德鑫;李紅梅;梁明;;納米抗菌塑料的抗菌性能測定[J];中國消毒學(xué)雜志;2006年04期

4 鐘金棟,夏雪山,張若愚,高毅穎;納米銀材料抗菌效果研究及其安全性初步評價[J];昆明理工大學(xué)學(xué)報(理工版);2005年05期

5 吳迎春;徐章法;;液相法制備納米TiO_2微粒的研究進展[J];鹽城工學(xué)院學(xué)報;2001年04期

6 汪山，，程繼健;磷酸鹽玻璃緩釋材料應(yīng)用進展[J];玻璃與搪瓷;1999年03期

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