本文選題：鹽酸羅匹尼羅 + 滲透泵型控釋片��； 參考：《西北藥學(xué)雜志》2016年02期

【摘要】：目的建立一種測定動物血漿中鹽酸羅匹尼羅的方法,并進(jìn)行鹽酸羅匹尼羅滲透泵型控釋片的藥物動力學(xué)研究,并計算與參比制劑(Requip XL)的相對生物利用度。方法 6只Beagle犬分別單次口服鹽酸羅匹尼羅滲透泵片(受試制劑)和Requip XL(參比制劑)1片,用LC-MS法測定血漿中的藥物濃度,計算藥物動力學(xué)參數(shù)和相對生物利用度。結(jié)果參比制劑和受試制劑的主要藥代動力學(xué)參數(shù)tmax分別為(2.92±0.49)和(3.58±0.49)h,Cmax分別為(2.60±0.41)和(2.35±0.39)ng·mL-1,MRT分別為(7.76±0.89)和(8.48±0.59)h,t1/2(Ke)分別為(4.70±0.67)和(5.94±1.19)h,AUC(0~t)分別為(16.06±5.55)和(17.90±2.75)ng·mL-1·h,AUC(0~∞)分別為(16.71±5.87)和(19.03±3.08)ng·mL-1·h,受試制劑相對于參比制劑的相對生物利用度Fr為111.48%。結(jié)論統(tǒng)計結(jié)果顯示,各主要藥動學(xué)參數(shù)均無顯著性差異。本方法能測定口服鹽酸羅匹尼羅滲透泵的血藥濃度,進(jìn)行動物藥物動力學(xué)和相對生物利用度研究。
[Abstract]:Objective to establish a method for the determination of ropioniclol hydrochloride in animal plasma and to study the pharmacokinetics of the controlled release tablets of ropiniro hydrochloride osmotic pump, and to calculate the relative bioavailability with reference preparation (Requip XL). Methods six Beagle dogs were treated with single oral tablets of ropiniro hydrochloride osmotic pump tablets (test preparation) and Requip XL1 tablets respectively. Plasma concentrations were determined by LC-MS method and pharmacokinetic parameters and relative bioavailability were calculated. 緇撴灉鍙傛瘮鍒跺墏鍜屽彈璇曞埗鍓傜殑涓昏鑽唬鍔ㄥ姏瀛﹀弬鏁皌max鍒嗗埆涓，

本文編號：1934884