本文選題：高血壓 + 腦白質(zhì)病�。� 參考：《中國(guó)神經(jīng)精神疾病雜志》2015年02期

【摘要】：目的探討瑞舒伐他汀鈣對(duì)慢性高血壓大鼠的腦白質(zhì)病變及其空間認(rèn)知功能障礙的影響。方法雄性Sprague-Daw Iey大鼠49只,隨機(jī)分為假手術(shù)組、高血壓組和瑞舒伐他汀鈣治療組(10 mg/kg)。高血壓組和瑞舒伐他汀鈣治療組采用雙腎雙夾法制作易卒中型腎血管性高血壓大鼠(stroke-prone renovascular hypertensive rat,RHRSP)模型,定期監(jiān)測(cè)血壓。水迷宮實(shí)驗(yàn)檢測(cè)空間記憶功能;Luxol fast blue染色觀察腦白質(zhì)疏松程度;免疫熒光法觀察額葉皮層β-淀粉樣蛋白(β-amyloid,Aβ)在大腦皮層的沉積分布;原位末端轉(zhuǎn)移酶標(biāo)記染色法(Td T-mediated d UTP-biotin nick end labeling,TUNEL)觀察額葉皮層細(xì)胞凋亡水平。結(jié)果 RHRSP大鼠造模后血壓逐漸升高,明顯高于假手術(shù)組(P0.01);瑞舒伐他汀鈣較高血壓組逃避潛伏期時(shí)間明顯縮短(P0.01),3組大鼠跨越平臺(tái)次數(shù)分別為(4.55±1.23)、(1.00±0.80)、(3.79±0.95),差異有統(tǒng)計(jì)學(xué)意義(P0.01)。與高血壓組相比,瑞舒伐他汀鈣可改善腦白質(zhì)疏松程度(P0.01),減少額葉皮層區(qū)Aβ沉積(17.47±3.59 vs.4.42±1.57,P0.01)及細(xì)胞凋亡(37.84±4.73 vs.14.42±2.43,P0.01)。結(jié)論瑞舒伐他汀鈣可改善慢性高血壓大鼠的腦白質(zhì)病變,減少額葉皮層區(qū)Aβ沉積以及細(xì)胞凋亡從而保護(hù)大鼠的空間記憶功能。
[Abstract]:Objective to investigate the effects of rosuvastatin calcium on white matter lesions and spatial cognitive impairment in chronic hypertensive rats. Methods Forty-nine male Sprague-Daw Iey rats were randomly divided into three groups: sham operation group, hypertension group and rosuvastatin calcium treatment group. Hypertension group and rosuvastatin calcium treatment group were used to make stroke-prone renovascular hypertensive RHRSPs model by double kidney and double clip method, and blood pressure was monitored regularly. Water maze test was used to detect the degree of leukoaraiosis by Luxol fast blue staining and the distribution of 尾 -amyloid A 尾 in the frontal cortex by immunofluorescence. Tunel was used to observe the apoptosis level of frontal cortex cells by in situ terminal transferase labeling staining (TD T-mediated d UTP-biotin nick end Tunel staining). Results the blood pressure of RHRSP rats increased gradually, which was significantly higher than that of sham operation group (P 0.01), and the escape latency time of rosuvastatin calcium group was significantly shorter than that of hypertension group (P 0.01). The times of crossing the platform of rats in the three groups were 4.55 鹵1.23, 1.00 鹵0.80 and 3.79 鹵0.95respectively, and the difference was statistically significant (P 0.01). Compared with hypertension group, rosuvastatin calcium could improve the degree of leukoaraiosis and reduce A 尾 deposition in frontal cortex area (17.47 鹵3.59 vs.4.42 鹵1.57 vs.4.42, P 0.01) and apoptosis (37.84 鹵4.73 vs.14.42 鹵2.43 vs.14.42 鹵0.01g / L). Conclusion Risuvastatin calcium can improve the white matter lesion of chronic hypertensive rats, reduce A 尾 deposition in the frontal cortex and protect the spatial memory function of the rats.
【作者單位】： 中山大學(xué)附屬第一醫(yī)院神經(jīng)科 教育部國(guó)家重點(diǎn)學(xué)科 衛(wèi)生部國(guó)家臨床重點(diǎn)專科 廣東省重大神經(jīng)疾病診治研究重點(diǎn)實(shí)驗(yàn)室;香港中文大學(xué)威爾斯親王醫(yī)院內(nèi)科與藥物治療系;
【基金】：國(guó)家自然科學(xué)青年基金(編號(hào):81000514) 廣東省自然科學(xué)基金項(xiàng)目(編號(hào):s2013010015840)
【分類號(hào)】：R965

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