本文選題：米托蒽醌 + 透明質(zhì)酸��； 參考：《鄭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年05期

【摘要】：目的:考察透明質(zhì)酸(HA)修飾的氧化石墨烯(GO)負(fù)載米托蒽醌(MIT)載藥體系(MIT/HA-GO)在乳腺癌模型裸鼠體內(nèi)的藥動學(xué)特征和組織分布。方法:建立MIT測定的高效液相色譜法。荷瘤小鼠由尾靜脈分別注射MIT、MIT/GO以及MIT/HA-GO,用上述方法檢測MIT濃度,分析其在小鼠體內(nèi)的藥動學(xué)特征及在心、肝、肺、腎、瘤等部位的分布情況。結(jié)果:與MIT組相比,MIT/GO組及MIT/HA-GO組MIT的血循環(huán)時(shí)間均延長,且在心、肺、腎的AUC降低;MIT/GO及MIT/HA-GO在腫瘤組織的靶向效率分別為MIT的1.55和2.61倍。結(jié)論:MIT/HA-GO載藥體系降低了MIT的全身毒副作用并提高了對腫瘤部位的靶向性。
[Abstract]:Aim: to investigate the pharmacokinetic characteristics and tissue distribution of mitoxantrone (mitoxantrone) -loaded mitoxantrone (mitoxantrone) loaded with hyaluronic acid (HA) in nude mice with breast cancer. Methods: high performance liquid chromatography (HPLC) was established for the determination of MIT. Mice bearing tumor were injected into tail vein with Mitt / MIT / go and MIT / HA-GO.The concentration of MIT was detected by the above method, and the pharmacokinetic characteristics and distribution of heart, liver, lung, kidney and tumor in mice were analyzed. Results: compared with the MIT group, the blood circulation time of MIT in both the mitr / go group and the MIT/HA-GO group was prolonged, and the AUC in heart, lung and kidney decreased the targeting efficiency of MIT/HA-GO and MIT/HA-GO in tumor tissue by 1.55 and 2.61 times of MIT, respectively. Conclusion the MIT system can reduce the systemic toxicity of MIT and improve the targeting of tumor site.
【作者單位】： 鄭州大學(xué)藥學(xué)院;
【基金】：國家自然科學(xué)基金資助項(xiàng)目81202485,81273451
【分類號】：R-332;R965
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本文編號：1789857