本文選題：溴甲納曲酮 + 季N-烷基嗎啡喃生物堿鹽��； 參考：《光譜實驗室》2013年04期

【摘要】：溴甲納曲酮可經(jīng)過兩步化學反應而獲得,以鹽酸納曲酮為起始原料,經(jīng)過氨水游離成游離納曲酮堿,再與溴甲烷反應制備季N-烷基嗎啡喃生物堿鹽的粗品,粗品經(jīng)過特殊精制手段達到除去常規(guī)精制方法難以除去的雜質(zhì),兩個反應操作均較簡易,本文獻的特色點是反應路線比較簡單,合成制備季N-烷基嗎啡喃生物堿鹽方法新穎,避開專利中的常規(guī)制備方法。除此之外,通過該粗品精致方案,能獲得更少雜質(zhì)的主產(chǎn)品,解決雜質(zhì)限度難以低于千分之一的難題。
[Abstract]:Bromo-naltrexone can be obtained by two-step chemical reaction. Naltrexone hydrochloride is used as the starting material, free naltrexone alkaloids are dissociated through ammonia water, and then reacted with methyl bromide to prepare crude N-alkyl morphine alkaloids of quaternary N-alkyl morphine alkaloids.The crude product was purified by special means to remove impurity which is difficult to be removed by conventional refining method. The two reaction operations are both relatively simple. The characteristic point of this document is that the reaction route is relatively simple, and the method of preparing quaternary N-alkyl morphine alkaloid alkaloid salt is novel.Avoid conventional preparation methods in patents.In addition, through this refined coarse product, the main product with less impurity can be obtained, and the impurity limit is difficult to be lower than 1/1000.
【作者單位】： 重慶醫(yī)科大學藥學院;
【分類號】：TQ463
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本文編號：1765643