本文選題：奧卡西平 + 納米脂質(zhì)載體��； 參考：《中國(guó)藥學(xué)雜志》2017年07期

【摘要】：目的制備奧卡西平納米脂質(zhì)載體(oxcarbazepine nanostructured lipid carriers,OXC-NLC),并對(duì)其理化性質(zhì)進(jìn)行考察。方法采用乳化溶劑蒸發(fā)法制備OXC-NLC,正交試驗(yàn)篩選最優(yōu)處方,使用掃描電鏡、激光粒徑測(cè)定儀、差示掃描量熱儀等考察OXC-NLC的理化性質(zhì),通過(guò)溶出試驗(yàn)評(píng)價(jià)其體外釋放效果。結(jié)果按優(yōu)化條件制備的OXC-NLC為類球形粒子,平均粒徑為(63.04±2.05)nm,粒度分布較均勻,Zeta電位為(-33.52±0.34)mV,DSC結(jié)果表明,藥物以無(wú)定形狀態(tài)分散于納米粒中,包封率為(98.16±1.59)%,載藥量為(4.27±0.70)%,體外8 h累積釋放27.31%。結(jié)論采用乳化溶劑蒸發(fā)法制備的OXC-NLC粒徑大小分布均勻,藥物包封率高,具有明顯的緩釋效果。此制備工藝流程簡(jiǎn)單、可靠、重現(xiàn)性好。
[Abstract]:Objective to prepare oxcarbazepine nanostructured lipid carriers OXC-NLCL and investigate their physical and chemical properties.Methods OXC-NLC was prepared by emulsifying solvent evaporation method. The optimum prescription was screened by orthogonal test. The physicochemical properties of OXC-NLC were investigated by scanning electron microscope, laser particle size analyzer and differential scanning calorimeter. The release effect in vitro was evaluated by dissolution test.Results the OXC-NLC prepared under the optimized conditions was spherical particles with an average particle size of 63.04 鹵2.05 nm, and the average particle size distribution was -33.52 鹵0.34 渭 m 路min ~ (-1). The results showed that the drug was dispersed in an amorphous state, the entrapment efficiency was 98.16 鹵1.59m, the drug loading was 4.27 鹵0.70nm, and the cumulative release was 27.31% at 8 h in vitro.Conclusion the OXC-NLC prepared by emulsified solvent evaporation has uniform particle size distribution, high encapsulation efficiency and obvious slow release effect.The process is simple, reliable and reproducible.
【作者單位】： 臺(tái)州職業(yè)技術(shù)學(xué)院化學(xué)制藥研究所;
【基金】：浙江省自然科學(xué)基金資助項(xiàng)目(LY14E050001) 浙江省教育廳一般科研項(xiàng)目(Y201432771) 臺(tái)州市科技計(jì)劃項(xiàng)目(1402ky18,15gy58) 臺(tái)州職業(yè)技術(shù)學(xué)院博士后科研啟動(dòng)基金項(xiàng)目(2016BSH01)
【分類號(hào)】：R943

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