本文選題：苯磺酸氨氯地平葉酸片　切入點(diǎn)：藥代動(dòng)力學(xué)　出處：《中國(guó)臨床藥理學(xué)雜志》2015年15期

【摘要】：目的研究健康受試者單劑量口服苯磺酸氨氯地平葉酸片和苯磺酸氨氯地平的藥代動(dòng)力學(xué)。方法用自身對(duì)照、三周期、拉丁方交叉試驗(yàn)設(shè)計(jì)。24名健康受試者單劑量口服苯磺酸氨氯地平葉酸片(5.4 mg),苯磺酸氨氯地平葉酸片(5.8 mg)或苯磺酸氨氯地平片(5 mg),用LC-MS/MS法測(cè)定血漿中氨氯地平,計(jì)算其主要藥代動(dòng)力學(xué)參數(shù)。用DAS軟件對(duì)主要藥代動(dòng)力學(xué)參數(shù)進(jìn)行比較。結(jié)果苯磺酸氨氯地平葉酸片(5.4 mg)、苯磺酸氨氯地平葉酸片(5.8 mg)和苯磺酸氨氯地平片(5 mg)中氨氯地平的主要藥代動(dòng)力學(xué)參數(shù):AUC0-t分別為(115.30±28.12),(119.42±32.80),(113.19±27.08)ng·m L-1·h;Cmax分別為(2.59±0.60),(2.59±0.50),(2.56±0.59)ng·m L-1;t1/2分別為(38.90±9.27),(33.85±11.31),(40.66±7.05)h。結(jié)論 3種藥物的主要藥代動(dòng)力學(xué)參數(shù)無顯著性差異。
[Abstract]:Objective to study the pharmacokinetics of amlodipine benzenesulfonic acid tablets and amlodipine benzenesulfonate tablets in healthy volunteers.Methods Self-control, three cycles,Latin square cross test design. 24 healthy volunteers were given amlodipine benzenesulfonic acid tablets (5.4 mg / g), amlodipine benzenesulfonate tablets (5.8 mg / L) or amlodipine benzenesulfonate tablets (5 mg / g). Amlodipine in plasma was determined by LC-MS/MS method.The main pharmacokinetic parameters were calculated.The main pharmacokinetic parameters were compared with DAS software.緇撴灉鑻：閰告皚姘湴騫沖彾閰哥墖(5.4 mg),鑻：閰告皚姘湴騫沖彾閰哥墖(5.8 mg)鍜岃嫰紓洪吀姘ㄦ隘鍦板鉤鐗，

本文編號(hào)：1727841