本文選題：離子色譜　切入點(diǎn)：直接電導(dǎo)法　出處：《藥物分析雜志》2017年11期

【摘要】：目的:建立離子色譜-直接電導(dǎo)法測定鹽酸二甲雙胍藥物中二甲胺殘留的方法。方法:鹽酸二甲雙胍藥物用水溶解后直接進(jìn)樣,采用20 mmol·L~(-1)甲磺酸水溶液為淋洗液,以Dionex Ionpac CS12A(4 mm×250 mm)色譜柱進(jìn)行分離,流速為1.0 m L·min~(-1),CSRS 500-4 mm陽離子抑制器和電導(dǎo)檢測器抑制并直接檢測,抑制電流60 m A,柱溫30℃,進(jìn)樣體積25μL。結(jié)果:二甲胺在0.1~10.0μg·m L~(-1)范圍內(nèi)線性關(guān)系良好(r=0.999 4),方法的檢測限為0.032 8μg·m L~(-1)(S/N=3),方法的定量下限為0.12μg·m L~(-1)(S/N=10),平均回收率為97.6%~99.5%,RSD均不超過3%。結(jié)論:該方法操作簡單、靈敏度高、重現(xiàn)性好,可用于鹽酸二甲雙胍藥物中二甲胺殘留的檢測。
[Abstract]:Objective: to establish an ion chromatography-direct conductance method for the determination of metformin hydrochloride residues in metformin hydrochloride. A Dionex Ionpac CS12A(4 mm 脳 250mm column was used to separate the column. The flow rate was 1.0 mL / min ~ (-1) and CSRS 500-4 mm cationic suppressor and conductance detector were suppressed and detected directly. The suppression current was 60 Ma and the column temperature was 30 鈩，

本文編號：1693424