本文選題：MTH酶　切入點(diǎn)：嘌呤核苷酸氧化損傷　出處：《中國(guó)藥理學(xué)通報(bào)》2016年08期

【摘要】：MTH1酶屬于Nudix水解酶,具有清理細(xì)胞核苷酸池內(nèi)氧化嘌呤核苷酸,防止核酸氧化損傷的功能。多項(xiàng)研究表明MTH1酶在神經(jīng)退行性疾病、抗衰老等,尤其是抗腫瘤方面發(fā)揮關(guān)鍵作用,有望成為抗腫瘤藥物的新靶標(biāo)。近年國(guó)內(nèi)外有關(guān)MTH1酶抑制劑的研究也逐漸增多,該文概述了MTH1酶的轉(zhuǎn)錄和翻譯、結(jié)構(gòu)特點(diǎn)、催化機(jī)制、應(yīng)用等各方面信息,特別是對(duì)其各類抑制劑的研究現(xiàn)狀進(jìn)行了較為全面的綜述。
[Abstract]:MTH1 enzyme belongs to Nudix hydrolase. It has the function of clearing the nucleotide oxidation in the nucleotide pool and preventing the oxidative damage of nucleic acid. Many studies have shown that MTH1 enzyme plays a key role in neurodegenerative diseases, anti-aging, especially in anti-tumor. It is expected to be a new target of antitumor drugs. In recent years, the research on MTH1 enzyme inhibitors has been increasing in China and abroad. In this paper, the transcription and translation, structural characteristics, catalytic mechanism, application and other information of MTH1 enzyme are summarized. In particular, the research status of various inhibitors is reviewed.
【作者單位】： 青島科技大學(xué)化工學(xué)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No 21072111,21272131)
【分類號(hào)】：R96

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