本文選題：SIIA-CA　切入點：SIIA-CB　出處：《中國抗生素雜志》2015年12期 　論文類型：期刊論文

【摘要】：目的研究絲狀真菌SIIA-F1108發(fā)酵液中抗真菌的活性成分。方法利用大孔吸附樹脂吸附、正相硅膠色譜層析和高壓液相制備等技術(shù),結(jié)合白念珠菌抑菌實驗進行跟蹤檢測,分離絲狀真菌SIIA-F1108的發(fā)酵液中的活性組分;通過紫外光譜、紅外光譜、高分辨質(zhì)譜、核磁共振進行分析,確定活性組分的結(jié)構(gòu)。結(jié)果分離純化得到SIIA-C1108A和SIIA-C1108B活性組分,分子式均為C_(50)H_(80)N_8O_(17),與文獻報道的紐莫康定(pneumocandin)B_0和C_0同質(zhì)。結(jié)論從絲狀真菌SIIA-F1108的發(fā)酵液中分離得到的兩個具有抗真菌活性物質(zhì)分別為紐莫康定B_0和C_0,其中紐莫康定B_0作為合成醋酸卡泊芬凈的前體物質(zhì),具備重要的經(jīng)濟價值。
[Abstract]:Objective to study the antifungal active components in filamentous fungi SIIA-F1108 fermentation broth. Methods the methods of macroporous adsorption resin adsorption, silica gel chromatography and high pressure liquid phase preparation were used to trace and detect candida albicans. The active components in the fermentation broth of filamentous fungus SIIA-F1108 were isolated, and the structures of the active components of SIIA-C1108A and SIIA-C1108B were determined by UV, IR, HRMS and NMR. Results the active components of SIIA-C1108A and SIIA-C1108B were isolated and purified. The molecular formula is Che _ (50) H _ (+) ~ (80) / N _ (8) O _ (+) _ (17) _ _ _. Synthesis of Carpofensin Acetate precursor, Have important economic value.
【作者單位】： 成都大學(xué)四川抗菌素工業(yè)研究所;
【分類號】：R914

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