本文選題：卡鉑　切入點：緩釋　出處：《中國藥房》2017年34期 　論文類型：期刊論文

【摘要】：目的:為選擇制備卡鉑緩釋微粒的材料提供參考。方法:以"卡鉑""緩釋""微粒""Carboplatin""Release""Microparticle"等為關(guān)鍵詞,組合查詢1997年1月-2017年4月在中國知網(wǎng)、Pub Med、Web of Science、Elsevier等數(shù)據(jù)庫中的相關(guān)文獻,對常用的制備卡鉑緩釋微粒的材料特點、制備方法及國內(nèi)外相關(guān)研究等方面進行綜述。結(jié)果與結(jié)論:共檢索到相關(guān)文獻193篇,其中有效文獻26篇。常用的制備卡鉑緩釋微粒的材料有聚乳酸-羥基乙酸共聚物(PLGA)、聚己內(nèi)酯(PCL)、明膠、海藻酸鹽/殼聚糖及其他材料。PLGA的降解時間可通過改變丙交酯和乙交酯的比例使其從幾天變到幾年,可通過更復(fù)雜的表面修飾使PLGA微粒的靶向性更強、到達靶器官的藥物濃度更高。但PLGA的制備方法目前難以應(yīng)用于大規(guī)模的生產(chǎn),其重現(xiàn)性和穩(wěn)定性還有待提高。PCL不僅可主動和被動地靶向腫瘤組織,而且能避免卡鉑給藥的溶血副作用。但PCL目前的研究均是在體外及動物體內(nèi)進行,進入人體的研究相對較少。明膠材料的優(yōu)點包括易乳化、水溶性、成膜、彈性和天然可生物降解,然而其微粒普遍表現(xiàn)出突釋現(xiàn)象,想要制備出緩釋性能更好的傳遞系統(tǒng),需要與其他材料聯(lián)合應(yīng)用。海藻酸鈉/殼聚糖微粒能有效地保留高分子的生物活性,作為負(fù)載各種藥劑及食品抗菌劑的包埋材料在醫(yī)藥、食品工業(yè)和化妝品等領(lǐng)域中具有良好的應(yīng)用前景。但對于卡鉑的包載,其受到氯離子的影響,包封率較低。雖然每種緩釋材料的特性不同,對卡鉑的包載程度不一,但制備出的緩釋微粒均比卡鉑溶液具有更穩(wěn)定的化學(xué)性質(zhì)、更長的緩釋時間、更強的靶向作用以及更低的全身毒性。今后應(yīng)從卡鉑緩釋微粒載藥量和包封率的進一步提高、藥物釋放速率及緩釋時間的精確控制、緩釋體系的表面改性及多種緩釋體系的聯(lián)合應(yīng)用等方面進行深入研究。
[Abstract]:Objective: to provide a reference for the selection of materials for the preparation of carboplatin sustained release particles. Methods: taking "carboplatin", "sustained release", "Carboplatin", "Release", "Microparticle" and so on as keywords, the relevant documents in the database Pub Meden of Scienceof Science Elsevier from January 1997 to April 2017 were searched. The material characteristics, preparation methods and related research of carboplatin sustained-release particles were reviewed. Results and conclusion: 193 related literatures were retrieved. The commonly used materials for preparation of carboplatin sustained-release particles are poly (lactic acid-glycolic acid) (PLGA), polycaprolactone (PCL), gelatin, polycaprolactone (PCL), polycaprolactone (PCL) and gelatin. The degradation time of alginate / chitosan and other materials. PLGA can be changed from a few days to a few years by changing the ratio of lactide to glycolide, and the targeting of PLGA particles can be enhanced by more complex surface modification. However, the preparation method of PLGA is difficult to be used in large-scale production, and its reproducibility and stability need to be improved. In addition, the hemolytic side effects of carboplatin administration can be avoided. However, the current studies of PCL are carried out in vitro and in vivo, but relatively few studies have been carried out into human body. The advantages of gelatin materials include easy emulsification, water solubility and membrane formation. Elastic and naturally biodegradable, however, the particles generally exhibit sudden release, and they want to produce a delivery system with better slow-release properties. Sodium alginate / chitosan particles can effectively retain the biological activity of polymers and are used as encapsulation materials for various pharmaceutical and food antimicrobial agents. Food industry, cosmetics and other fields have good application prospects. However, for carboplatin encapsulation, it is affected by chloride ions, and the encapsulation efficiency is low. Although the properties of each kind of sustained-release materials are different, the degree of encapsulation of carboplatin varies. However, the prepared slow-release particles have more stable chemical properties, longer sustained release time, stronger targeting effect and lower systemic toxicity than carboplatin solution. In the future, the drug loading and encapsulation efficiency of carboplatin slow-release particles should be further increased. The precise control of drug release rate and release time, the surface modification of sustained release system and the combined application of several slow release systems were studied in detail.
【作者單位】： 吉林大學(xué)口腔醫(yī)院修復(fù)科;吉林大學(xué)第二醫(yī)院婦產(chǎn)科;
【基金】：吉林省科技發(fā)展計劃項目(No.20140311088YY、20150204004YY、201603028YY) 長春市科技計劃項目(No.14KG049、16ss12)
【分類號】：R943
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本文編號：1624539