本文選題：馬來酸桂哌齊特　切入點(diǎn)：心肌損傷　出處：《中國(guó)藥學(xué)雜志》2017年18期 　論文類型：期刊論文

【摘要】：目的探討馬來酸桂哌齊特(cinepazide maleate,CM)對(duì)異丙腎上腺素(Iso)所致大鼠心肌損傷的保護(hù)作用及其作用機(jī)制。方法將雌雄大鼠50只分為正常組,模型組,CM低、高劑量組,卡托普利(captopril,Cap)陽性組。除正常組外,其余各組大鼠以Iso(5 mg·kg~(-1)·d~(-1))皮下注射7 d建立心肌損傷模型,治療組大鼠于造模第2天開始腹腔注射CM(1.5、3 mg·kg~(-1)·d~(-1)),陽性對(duì)照組大鼠灌胃給予Cap(10 mg·kg~(-1)·d~(-1)),正常組和模型組大鼠腹腔注射等量生理鹽水,共給藥14 d。各組大鼠進(jìn)行3次跑步耐力測(cè)試。停藥后大鼠麻醉狀態(tài)下描記心電圖、取血和取心,測(cè)量心重指數(shù)(HWI)及左心室重量指數(shù)(LHWI),檢測(cè)心肌組織中羥脯氨酸(Hyp)含量和丙二醛(MDA)水平,血清中乳酸脫氫酶(LDH)和肌酸激酶(CK)活性及超氧化物歧化酶(SOD)活力;HE染色觀察心肌組織形態(tài)學(xué)變化。結(jié)果與正常組比較,模型組大鼠耐力值下降,心電異常,呈心律不齊或心肌缺血波形,同時(shí)HWI和LHWI增高(P0.01),心肌組織中Hyp含量和MDA水平以及血清LDH、CK水平均增高,而血清SOD活力降低(P0.05或P0.01);與模型組比較,CM治療組耐力值明顯提高、心電異�，F(xiàn)象明顯改善,大鼠HWI和LHWI均降低,組織中Hyp含量、MDA水平以及血清LDH和CK水平均降低,而SOD活力增高,尤其CM高劑量組效果明顯(P0.01)。HE染色:模型組大鼠心室肌結(jié)構(gòu)重塑,心肌斷裂,大量膠原纖維增生,CM治療組大鼠心室肌重構(gòu)現(xiàn)象減輕,心肌纖維化明顯改善。結(jié)論馬來酸桂哌齊特對(duì)Iso所致大鼠心肌損傷有保護(hù)作用。
[Abstract]:Objective to investigate the protective effect and mechanism of cinepazide maleate maleate maleate (CMCM) on myocardial injury induced by isoprenaline (Iso) in rats. Methods 50 male and female rats were divided into normal group, model group, low dose group and high dose group. In captopril captopril captopril positive group, the myocardial injury model was established by subcutaneous injection of Iso(5 mg 路kg ~ (-1) 路d ~ (-1) 路D ~ (-1) in all rats except the normal group for 7 days. On the second day, rats in the treatment group were given intraperitoneal injection of CMV 1.5g 路kg ~ (-1) 路d ~ (-1), the rats of the positive control group were given Cap(10 mg 路kg ~ (-1) 路dan-1 ~ (-1) by intraperitoneal injection of normal saline, and the normal group and the model group were injected intraperitoneally with the same amount of normal saline, and the rats in the control group were given intraperitoneal injection of Cap(10 mg 路kg ~ (-1). The rats were given for 14 days. The rats in each group were tested for three times of running endurance. The electrocardiogram, blood and heart of the rats were recorded under anaesthesia after withdrawal of the drug. Cardiac weight index (HWI) and left ventricular mass index (LHWII) were measured. The content of hydroxyproline (HypHypHyp) and the level of malondialdehyde (MDA) in myocardium were measured. The activity of lactate dehydrogenase (LDH) and creatine kinase (CK) and the activity of superoxide dismutase (SOD) in serum were observed by HE staining. There were arrhythmia or myocardial ischemia wave, while HWI and LHWI increased P0.01A, the contents of Hyp and MDA in myocardial tissue and the level of serum LDH- CK increased, while the activity of serum SOD decreased (P0.05) or P0.01.The endurance value of CM-treated group was significantly higher than that of model group. The abnormal phenomenon of ECG was obviously improved, HWI and LHWI were decreased, the content of Hyp and serum LDH and CK were decreased, and the activity of SOD was increased, especially in CM high dose group. Myocardial rupture, proliferation of collagen fibers and myocardial fibrosis were alleviated in CM group. Conclusion Cinepazide maleate has protective effect on myocardial injury induced by Iso in rats.
【作者單位】： 吉林醫(yī)藥學(xué)院基礎(chǔ)醫(yī)學(xué)院實(shí)驗(yàn)中心;吉林醫(yī)藥學(xué)院臨床醫(yī)學(xué)院;
【基金】：吉林省教育廳“十二五”科學(xué)技術(shù)研究資助項(xiàng)目(2015396) 2016年吉林省“大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃”資助項(xiàng)目(2016B314)
【分類號(hào)】：R965

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