本文選題：利奈唑胺　切入點：合理用藥　出處：《中國醫(yī)院藥學(xué)雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的:綜合評價某綜合教學(xué)醫(yī)院住院患者使用利奈唑胺的適宜性、有效性和安全性。方法:采用回顧性研究方法,選取廣州市某三甲醫(yī)院2015年1月-2015年12月使用利奈唑胺注射劑或片劑的患者病例,根據(jù)藥品說明書和相關(guān)指南,分析利奈唑胺的應(yīng)用情況,并統(tǒng)計有效率及不良反應(yīng)發(fā)生率。結(jié)果:共納入有效病例232例,評價結(jié)果合理的有186例(80.17%),不合理的有46例(19.83%);治療結(jié)果痊愈118例(50.86%),顯效48例(20.69%),進(jìn)步21例(9.05%),無效45例(19.40%)。用藥后出現(xiàn)不良反應(yīng)的有69例(29.74%),其中血小板減少50例(21.55%),白細(xì)胞減少13例(5.56%),血紅蛋白減少9例(3.85%),惡心、嘔吐13例(5.56%),腹瀉6例(2.56%),皮疹4例(1.71%),乳酸性酸中毒3例(1.28%)。ICU患者血小板減少癥的發(fā)生率明顯高于非ICU患者(P=0.004),但片劑與注射劑、≥65歲與65歲患者間的發(fā)生率均無明顯差異(P值分別為0.152,0.148)。結(jié)論:利奈唑胺治療革蘭陽性球菌感染的療效較好,但臨床應(yīng)用存在不合理情況,發(fā)生血小板減少的比例較高,尤其是ICU患者,值得臨床關(guān)注。
[Abstract]:Objective: to evaluate synthetically the suitability, efficacy and safety of the use of linazolamide in inpatients of a general teaching hospital. According to the drug instruction and related guidelines, the cases of patients who used linazolamide injection or tablet from January 2015 to December 2015 in a third Class A Hospital of Guangzhou City were selected to analyze the application of linazolamide. The effective rate and incidence of adverse reactions were calculated. Results: 232 effective cases were included. The results of evaluation were reasonable in 186 cases (80.17), unreasonable in 46 cases (19.83), cure in 118 cases (50.86%), remarkable effect in 48 cases (20.6969%), improvement in 21 cases (9.05%), ineffective in 45 cases (19.400.75%), adverse reactions in 69 cases (29.7474%), of which 50 cases had thrombocytopenia (21.55%), and white blood cells (WBC) were decreased in 50 cases (21.55%). 13 cases reduced 5. 56%, 9 cases hemoglobin decreased 3. 85%, nausea, The incidence of thrombocytopenia was significantly higher in 13 patients with vomiting than in non-patients with ICU, but the incidence of thrombocytopenia in 3 patients with lactic acidosis was significantly higher than that in patients without ICU. There was no significant difference in the incidence rate between patients aged 鈮，

本文編號：1582058