本文選題：coenzyme　切入點：腸道吸收　出處：《藥學(xué)學(xué)報》2015年02期 　論文類型：期刊論文

【摘要】：正依折麥布是通過抑制腸道吸收膽固醇的作用機(jī)制降低體內(nèi)膽固醇的首創(chuàng)性藥物。1作用靶標(biāo)人體內(nèi)的膽固醇來源有兩個途徑:自身合成和膳食攝取。體內(nèi)近三分之二的膽固醇是自身合成的,由乙酰輔酶A經(jīng)30多個酶催化的生化反應(yīng)生成;其余部分來自于膳食,經(jīng)腸吸收進(jìn)入肝臟。負(fù)責(zé)膽固醇吸收的一個靶標(biāo),是�；o酶A膽固醇�；D(zhuǎn)移酶(acyl-coenzyme A cholesterol acyltransferase,ACAT)。ACAT是微粒體酶,負(fù)責(zé)將游離膽固醇轉(zhuǎn)變?yōu)橹舅?br/>[Abstract]:Zhengezebu is the first drug to reduce cholesterol in vivo by inhibiting the absorption of cholesterol in the gut. 1. There are two sources of cholesterol in target human body: self-synthesis and dietary intake. Nearly three-thirds in vivo. Bis cholesterol is self-synthesized, Acetyl coenzyme A is produced by biochemical reaction catalyzed by more than 30 enzymes; the rest comes from diet and is absorbed by intestine into the liver. A target responsible for cholesterol absorption is acyl-coenzyme A cholesterol acyltransferase A acyltransferase Acyltransferase ACATN. ACAT is a microsomal enzyme, and a target for cholesterol absorption is acyl-coenzyme A acyltransferase A acyltransferase A acyltransferase A acyltransferase. Responsible for converting free cholesterol into fatty acids
【作者單位】： 中國醫(yī)學(xué)科學(xué)院藥物研究所;
【分類號】：R91

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