本文關(guān)鍵詞： 離子色譜法 抗氧劑 亞硫酸鈉 硫酸依替米星注射液　出處：《中國(guó)藥學(xué)雜志》2017年20期 　論文類型：期刊論文

【摘要】：目的建立離子色譜法測(cè)定硫酸依替米星注射液中抗氧劑亞硫酸鈉含量的方法。方法采用DionexIonPac AS11-HC(4mm×250 mm)色譜柱,DionexIonPac AG11-HC(4 mm×50 mm)保護(hù)柱,以氫氧化鉀溶液為淋洗液進(jìn)行梯度淋洗,流速1.0 mL·min~(-1),抑制電流99 mA,電導(dǎo)檢測(cè)器檢測(cè),電導(dǎo)池溫度35℃,柱溫30℃。結(jié)果亞硫酸鈉在8~80μg·mL~(-1)內(nèi)線性關(guān)系良好;檢測(cè)限為0.02μg·mL~(-1)(S/N=3),定量限為0.09μg·mL~(-1)(S/N=10)。結(jié)論本實(shí)驗(yàn)建立的方法快速、準(zhǔn)確、重現(xiàn)性好,有助于制劑中亞硫酸鈉的用量控制。亞硫酸鈉作為抗氧劑有其使用的合理性,但樣品中濃度過(guò)高,其處方量尚待進(jìn)一步研究降低。
[Abstract]:Objective to establish a method for the determination of sodium sulfite in etimicin sulfate injection by ion chromatography. Methods the DionexIonPac AS11-HC(4mm 脳 250mm column was used to determine the content of sodium sulfite in etimicin sulfate injection. The protective column of Dionex IonPac AG11-HC(4 脳 50mm was used, and the solution of potassium hydroxide was used as eluent for gradient elution. The flow rate was 1.0 mL 路min ~ (-1) 路min ~ (-1), the inhibition current was 99 Ma, the conductivity detector was used to detect the conductivity cell temperature at 35 鈩，

本文編號(hào)：1542909