本文關(guān)鍵詞： 鎮(zhèn)咳藥 祛痰藥 研究進(jìn)展　出處：《中國(guó)藥房》2015年25期 　論文類型：期刊論文

【摘要】：目的:為開發(fā)新型鎮(zhèn)咳、祛痰藥物提供參考。方法:以"鎮(zhèn)咳藥""祛痰藥""研究進(jìn)展""Antitussive""Expectorant"等為關(guān)鍵詞,組合查詢2003-2014年中國(guó)知網(wǎng)、萬(wàn)方、Pub Med、Scopus等數(shù)據(jù)庫(kù)中的相關(guān)文獻(xiàn),將鎮(zhèn)咳藥物按受體的不同進(jìn)行分類分析,而祛痰藥物則按作用機(jī)制的不同進(jìn)行歸納。結(jié)果:共查詢到相關(guān)文獻(xiàn)80余條,有效文獻(xiàn)29條。其中具有良好開發(fā)前景的新型鎮(zhèn)咳藥物主要有速激肽受體拮抗藥、P2X受體拮抗藥、選擇性大麻素受體激動(dòng)藥、瞬時(shí)受體電位香草酸亞型1受體拮抗藥、p38絲裂原活化蛋白激酶抑制劑等;祛痰藥物的研究仍局限于黏液溶解藥、惡心性祛痰藥、黏液潤(rùn)滑藥3種。結(jié)論:目前,新型的鎮(zhèn)咳藥物已逐漸向療效更廣、更具受體選擇性的方向發(fā)展,而祛痰藥物則未見有較大的突破。
[Abstract]:Objective: to provide a reference for the development of new antitussive and expectorant drugs. Methods: taking "antitussive drugs," "expectorant drugs", "research progress", "Antitussive" and "Expectorant" as the keywords, the relevant documents in the database of "Pub MedScopus" from 2003 to 2014 in China were searched. The antitussive drugs were classified according to the different receptors, while the expectorant drugs were concluded according to the different mechanism of action. There are 29 effective documents. Among them, the new antitussive drugs with good development prospects are mainly the tachykinin receptor antagonists, P2X receptor antagonists, selective cannabinoid receptor antagonists, and the selective cannabinoid receptor antagonists. Transient receptor potential vanillic acid subtype 1 receptor antagonists, such as p38 mitogen-activated protein kinase inhibitors, and expectorant drugs are still limited to three kinds of mucolytic drugs, nausea expectorants and mucus lubricating drugs. The new antitussive agents have gradually developed towards wider efficacy and more receptor selectivity, while expectorant drugs have not made a great breakthrough.
【作者單位】： 中山大學(xué)中山醫(yī)學(xué)院;中山大學(xué)中山醫(yī)學(xué)院病理生理學(xué)教研室;
【基金】：2014年大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目(No.20140558075)
【分類號(hào)】：R974

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相關(guān)期刊論文 前10條

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本文編號(hào)：1533147