本文關(guān)鍵詞： 阿卡波糖 雜質(zhì)A 雜質(zhì)D 分離富集　出處：《浙江工業(yè)大學(xué)學(xué)報(bào)》2017年03期 　論文類(lèi)型：期刊論文

【摘要】：采用不同的酸、堿條件對(duì)阿卡波糖進(jìn)行降解反應(yīng),可得到其雜質(zhì)A和D,不同酸堿濃度、溫度和降解時(shí)間等條件對(duì)兩種雜質(zhì)的生成量有較大的影響.結(jié)果顯示在30℃和0.5moL/L的NaOH溶液中降解3h雜質(zhì)A組分產(chǎn)量較高;在25℃和12moL/L的HCl溶液中降解1h雜質(zhì)D組分產(chǎn)量較高.降解實(shí)驗(yàn)得到的粗品雜質(zhì)A和D經(jīng)制備液相色譜進(jìn)一步分離富集,分別得到高純度的兩種雜質(zhì),并采用高分辨質(zhì)譜對(duì)其進(jìn)行了結(jié)構(gòu)確認(rèn).實(shí)驗(yàn)對(duì)于提高阿卡波糖產(chǎn)品質(zhì)量標(biāo)準(zhǔn)具有重要意義.
[Abstract]:Different acid and base conditions were used to degrade acarbose, and impurities A and D were obtained, and different acid and base concentrations were obtained. The results showed that the yield of impurity A was higher in NaOH solution at 30 鈩，

本文編號(hào)：1526776