本文關(guān)鍵詞： 羅替戈汀 壓敏膠分散型貼劑 體外透皮 促透劑 制備 質(zhì)量評價　出處：《中國醫(yī)藥工業(yè)雜志》2015年06期 　論文類型：期刊論文

【摘要】：制備了含不同促透劑[月桂氮酮、油酸、N-甲基吡咯烷酮(NMP)、薄荷醇、萜品醇、庚酸薄荷醇酯(M-HEP)或油酸薄荷醇酯(M-OA)]的羅替戈汀壓敏膠分散型貼劑。采用雙室擴散池,以離體大鼠皮膚為屏障進行體外滲透試驗,考察了壓敏膠和促透劑的種類及濃度對貼劑中藥物滲透行為的影響。結(jié)果表明,以丙烯酸樹脂壓敏膠Duro-Tak 87-2677為基質(zhì),3%M-OA與10%NMP聯(lián)用時貼劑中羅替戈汀的累積透過量較高且無釋放時滯。初步穩(wěn)定性考察結(jié)果表明,該制品在30℃、相對濕度60%環(huán)境放置6個月,黏附性和透皮性能無顯著改變。市售制劑Neupro(規(guī)格2.4 mg/10 cm2)和自制品(規(guī)格5 mg/10 cm2)的24 h累積透過量為(254.34±46.16)和(499.36±53.27)?g/cm2。
[Abstract]:Different penetration enhancers were prepared. [Cinnamon azone, oleic acid N-methylpyrrolidone, menthol, terpene alcohol. Rotigotin pressure-sensitive adhesive dispersible patch of menthol heptanate (M-HEP) or oleic acid menthol ester (M-OA)]. In vitro osmotic test was carried out by using a double-chamber diffusion cell and isolated rat skin as barrier. The effects of the types and concentrations of pressure sensitive adhesive and permeability enhancer on the drug permeation behavior in the patch were investigated. The results showed that the acrylic resin pressure sensitive adhesive Duro-Tak 87-2677 was used as the matrix. (3) the cumulative transmittance of rotigotin in the patch was higher and there was no release delay when M-OA and 10NMP were used. The preliminary stability test showed that the product was at 30 鈩，

本文編號：1458168