本文關鍵詞：膦�；繉σ阴Ｄ憠A酯酶的抑制作用及中毒酶重活化特性研究——基于效應標志物質(zhì)譜定量分析技術　出處：《高等學�；瘜W學報》2017年05期 　論文類型：期刊論文

  更多相關文章： 有機磷農(nóng)藥 肟類化合物 膦�；� 生物標志物 液相色譜-質(zhì)譜聯(lián)用

【摘要】：將對氧磷(Paraoxon)與肟類重活化劑雙復磷(Obidoxime)反應制得膦酰化肟(DEP-obidoxime);利用基于效應標志物的質(zhì)譜定量技術研究了膦�；繉σ阴Ｄ憠A酯酶(AChE)的抑制作用及中毒酶的重活化特性.結果表明,膦�；烤哂袠O強的AChE抑制毒性,但因膦酰化肟中毒酶與原有機磷毒物中毒酶結構相同,故其膦�；疉ChE仍可被經(jīng)典重活化劑[如氯解磷定(Pralidoxime)、雙復磷(Obidoxime)及酰胺磷定(HI-6)]重活化,根據(jù)EC_(50)表征結果,這3種重活化劑的重活化效果強弱順序依次為氯解磷定HI-6雙復磷.
[Abstract]:The phosphonyl oxime (DEP-obidoxime) was synthesized by the reaction of paraoxon and oxime reactivator (Oxime). The inhibitory effect of phosphonyl oxime on acetylcholinesterase (ache) and the reactivation characteristics of toxic enzyme were studied by mass spectrometry quantitative technique based on effect markers. Phosphonyl oxime has very strong AChE inhibition toxicity, but because the phosphonyl oxime poisoning enzyme has the same structure as the original organophosphorus poisoning enzyme, its phosphonate AChE can still be used as the classical reactivator. [For example, Pralidoxime, Obidoxime and HI-6) were reactivated and characterized by ECS 50). The reactivation effect of these three reactivators was in the order of chlorolytic phosphoridated HI-6 double phosphorus.
【作者單位】： 軍事醫(yī)學科學院毒物藥物研究所;
【基金】：國家自然科學基金(批準號:81202248,81302473)資助~~
【分類號】：O657.63;R96
【正文快照】： 因有機氯農(nóng)藥導致的嚴重污染問題,自20世紀80年代初我國開始停止其使用[1],而有機磷農(nóng)藥作為一種高效、廣譜的殺蟲劑開始廣泛應用于農(nóng)業(yè)、工業(yè)及醫(yī)藥等領域.有機磷農(nóng)藥是目前世界上生產(chǎn)量和使用量最多的一類農(nóng)藥,我國有機磷農(nóng)藥產(chǎn)量占全世界總量的1/3.有機磷農(nóng)藥多屬于劇毒及，

本文編號：1421173