冠心病不同中醫(yī)證型患者PCI術后Lp-PLA2水平的對比研究
[Abstract]:Objective: to investigate the difference of Lp-PLA2 level among three TCM syndromes of coronary heart disease (phlegm turbid syndrome, blood stasis syndrome and qi deficiency syndrome) by detecting the level of plasma Lp-PLA2 in patients with coronary heart disease, to explore which TCM syndrome type of coronary heart disease has increased Lp-PLA2 level in which TCM syndrome type of coronary heart disease, and to analyze the severity of coronary artery disease in patients with traditional Chinese medicine syndrome type of coronary heart disease. To predict the possibility of recurrent coronary artery stenosis after PCI in patients with different TCM syndromes. Methods: 75 patients with coronary heart disease hospitalized in Department of Cardiovascular Medicine from April 2016 to December 2016 in Guangdong Integrated traditional Chinese and Western Medicine Hospital were selected as the study group. According to the syndrome differentiation criteria of traditional Chinese medicine, they were divided into three types: phlegm turbid syndrome, blood stasis syndrome and qi deficiency syndrome. The control group was 25 healthy subjects (between 40 years old and 90 years old, both male and female). Fasting blood was drawn from the eligible control group on admission, and fasting blood was drawn on the 1st and 4th day after operation, and the levels of Lp-PLA2 were measured by immunoturbidimetry. The levels of Lp-PLA2 in the study group and the healthy control group were compared, and the plasma Lp-PLA2 levels in the patients with different TCM syndrome types of coronary heart disease were compared on the 1st and 4th day after PCI, and the differences of Lp-PLA2 in the three groups of patients with coronary heart disease at different time points after percutaneous coronary intervention were compared. The results were analyzed by SPSS 19.0. Results: 1. The level of Lp-PLA2 in the study group was significantly higher than that in the healthy control group on the 1st and 4th day after operation (P 0.05). 2, the level of Lp-PLA2 in the three groups on the first day after PCI was not equal. Through pairwise comparison, the level of Lp-PLA2 was phlegm, turbid syndrome, blood stasis syndrome and qi deficiency syndrome. 3, On the 4th day after PCI, the level of Lp-PLA2 was not equal among the three groups of patients with different TCM syndromes. By pairwise comparison, the level of Lp-PLA2 was from high to low for phlegm and turbid syndrome, blood stasis syndrome and qi deficiency syndrome. 4. On the first day after coronary heart disease PCI, there were differences in Lp-PLA2 level among the three groups of different western medicine types of coronary heart disease. After statistical comparison, the level of Lp-PLA2 was AMIUAPSAP.5, from high to low. On the 4th day after PCI, the levels of Lp-PLA2 in the three groups were different among different types of coronary heart disease (CAD). By pairwise comparison, the Lp-PLA2 levels were arranged smoothly according to AMIUAPSAP. Conclusion: Lp-PLA2, as a strong vascular pro-inflammatory factor, can evaluate the activity of coronary artery disease, is an index to evaluate the severity of coronary artery disease, and can be used as an index to judge the possibility of coronary restenosis in patients with three different types of coronary heart disease after PCI. There are obvious differences in Lp-PLA2 level among different TCM syndrome differentiation patients of coronary heart disease after PCI, which can provide objective basis for TCM syndrome differentiation of coronary heart disease, guide the clinical use of traditional Chinese medicine for coronary heart disease, and can also be used as an objective index to judge which TCM syndrome type of coronary heart disease patients have greater possibility of recurrent stenosis after PCI.
【學位授予單位】:廣州中醫(yī)藥大學
【學位級別】:碩士
【學位授予年份】:2017
【分類號】:R541.4
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