發(fā)布時(shí)間：2019-06-25 19:50

【摘要】：目的:比較芪藶強(qiáng)心膠囊、復(fù)方丹參滴丸對(duì)急性心肌梗死(AMI)患者經(jīng)皮冠狀動(dòng)脈介入(PCI)術(shù)后無(wú)復(fù)流者相關(guān)指標(biāo)的影響。方法:90例AMI患者PCI術(shù)后存在無(wú)復(fù)流者隨機(jī)分為復(fù)方丹參滴丸組(45例)和芪藶強(qiáng)心膠囊組(45例)。PCI術(shù)前兩組患者均嚼服1次阿司匹林咀嚼片300 mg,硫酸氫氯吡格雷片300 mg。術(shù)后,兩組患者均嚼服阿司匹林咀嚼片100 mg,每日1次+辛伐他汀咀嚼片10 mg,每日1次。在此基礎(chǔ)上,復(fù)方丹參滴丸組患者給予復(fù)方丹參滴丸10丸,口服,每日3次;芪藶強(qiáng)心膠囊組患者給予芪藶強(qiáng)心膠囊4粒,口服,每日3次。兩組均連用6個(gè)月。觀察兩組患者治療前后心肌梗死溶栓治療(TIMI)血流分級(jí)、左心室射血分?jǐn)?shù)(LEVF)和β_1-腎上腺素能受體抗體(β_1-AR)、β_2-AR、α_1-AR水平,出血及主要心血管事件發(fā)生情況,并記錄不良反應(yīng)發(fā)生情況。結(jié)果:治療前,兩組患者TIMI血流分級(jí)、LEVF、β_1-AR、β_2-AR、α_1-AR水平比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者TIMI血流分級(jí)0~2級(jí)例數(shù)均顯著低于同組治療前,3級(jí)例數(shù)均顯著高于同組治療前;LEVF水平均顯著高于同組治療前,且芪藶強(qiáng)心膠囊組LEVF水平顯著高于復(fù)方丹參滴丸組;β_1-AR、β_2-AR、α_1-AR水平均顯著低于同組治療前,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者出血發(fā)生率、主要心血管事件發(fā)生率比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者治療期間均未見(jiàn)明顯不良反應(yīng)發(fā)生。結(jié)論:芪藶強(qiáng)心膠囊在改善AMI患者PCI術(shù)后無(wú)復(fù)流的效果、安全性方面與復(fù)方丹參滴丸相當(dāng),在改善心功能方面優(yōu)于復(fù)方丹參滴丸。
[Abstract]:Objective: to compare the effects of Qili Qiangxin capsule and compound Danshen dropping pills on the related indexes of non-reflow patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: 90 patients with AMI without reflow after PCI were randomly divided into compound Danshen dropping pill group (n = 45) and Qili Qiangxin capsule group (n = 45). Both groups were chewed with aspirin chewable tablet 300 mg, hydroclopidogrel sulfate 300 mg. before). PCI. The patients were randomly divided into two groups: compound salvia miltiorrhiza group (n = 45) and Qili Qiangxin capsule group (n = 45). After operation, the patients in both groups were chewed with aspirin chewing tablets once a day for 10 mg, once a day. On this basis, the patients in the compound Danshen dropping pill group were given 10 oral Danshen dropping pills, 3 times a day, and the patients in the Qili Qiangxin capsule group were given 4 Qili Qiangxin capsule, oral three times a day. Both groups were used for 6 months. The blood flow grading of (TIMI), left ventricular ejection fraction (LEVF) and 尾 _ 1-adrenergic receptor antibody (尾 _ 1-AR), 尾 _ 2 鈮，

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