【摘要】：目的:探討收縮壓(SBP)縱向軌跡與心房顫動(房顫)的關(guān)系。方法:以開灤研究中滿足標準的對象組成研究隊列。通過SAS Proc Traj程序確定觀察對象2006~2007、2008~2009、2010~2011年健康體檢的SBP縱向軌跡,生成5個不同的SBP軌跡組:低-穩(wěn)定軌跡組、中-穩(wěn)定軌跡組、中-高軌跡組、高-中軌跡組和高-穩(wěn)定軌跡組。采用Log-Rank檢驗比較不同SBP軌跡組于2012~2013、2014~2015年2次健康體檢時的房顫發(fā)病率的差異,采用多因素COX回歸模型分析不同SBP軌跡組與房顫的關(guān)系。結(jié)果:(1)40 727例納入研究,平均年齡(51.81±11.54)歲,其中,男性30 693例(75.4%)。低-穩(wěn)定軌跡組10 950例,中-穩(wěn)定軌跡組19 158例,中-高軌跡組3 736例,高-中軌跡組4 702例,高-穩(wěn)定軌跡組2 181例。(2)低-穩(wěn)定軌跡組、中-穩(wěn)定軌跡組、中-高軌跡組、高-中軌跡組和高-穩(wěn)定軌跡組房顫發(fā)病率分別為:0.1%、0.2%、0.5%、0.5%、0.6%(P均0.05)。(3)在多因素COX回歸分析中,校正其他混雜因素后,與低-穩(wěn)定軌跡相比,中-高軌跡、高-中軌跡、高-穩(wěn)定軌跡均是新發(fā)房顫的危險因素,對應(yīng)的HR(95%CI)分別為7.58(2.08~27.73)、5.30(1.88~14.95)、8.52(1.96~37.09)(P均0.05)。排除有心肌梗死病史、腦卒中病史者后,進行敏感性分析,結(jié)果與以上主要研究結(jié)果趨勢一致。結(jié)論:SBP縱向軌跡水平升高是新發(fā)房顫的危險因素。
[Abstract]:Objective: To study the relationship between the longitudinal trajectory of systolic blood pressure (SBP) and atrial fibrillation (AF). Methods: The study cohort was composed of the subjects that met the criteria in the open-hand study. The SBP longitudinal track of the healthy physical examination in 2006-2007,2008-2009 and 2010-2011 was determined by the SAS Proc Traj procedure, and five different SBP track groups were generated: low-stable track group, medium-stable track group, medium-high track group, high-middle track group and high-stable track group. Using Log-Rank test to compare the incidence of atrial fibrillation in different SBP track groups from 2012 to 2013 and 2014 to 2015, a multi-factor COX regression model was used to analyze the relationship between different SBP track groups and atrial fibrillation. Results: (1)40 727 cases were included in the study, the mean age (51.81, 11.54) years, among which, there were 3,693 males (75.4%). In the low-stable track group, there were 10,950, middle-stable track group (19,158), middle-high locus group (3,736), high-middle track group (4,702), high-stable track group (2,181). (2) The incidence of AF was 0.1%, 0.2%, 0.5%, 0.5% and 0.6%, respectively (P <0.05). (3) In the multi-factor COX regression analysis, compared with the low-stable trajectory, the middle-high locus, high-middle locus and high-stable locus were the risk factors of new AF, and the corresponding HR (95% CI) was 7.58 (2.08-27.73), 5.30 (1.88-14.95), 8.52 (1.96-37.09) (P <0.05). The history of myocardial infarction and the history of stroke were excluded. After the history of stroke, the sensitivity analysis was performed, and the results were consistent with the results of the above main research results. Conclusion: The increase in the level of the longitudinal trajectory of SBP is a risk factor for new AF.
【作者單位】： 華北理工大學附屬開灤總醫(yī)院心內(nèi)二科;華北理工大學研究生院;華北理工大學附屬醫(yī)院超聲科;
【分類號】：R541.75

【參考文獻】

相關(guān)期刊論文 前2條

1 趙振燕;吳永健;;2013歐洲心臟病學會(ESC)糖尿病、糖尿病前期及心血管疾病診療指南概述[J];中國循環(huán)雜志;2013年08期

2 黨愛民;陳炳偉;;2013歐洲高血壓學會/歐洲心臟病學會高血壓管理指南更新要點解讀[J];中國循環(huán)雜志;2013年06期

【共引文獻】

相關(guān)期刊論文 前10條

1 譚蓓;;便攜式血糖儀在信息化血糖管理中的應(yīng)用價值[J];醫(yī)療裝備;2017年12期

2 杜鑫;張芮英;張瑩;施繼紅;黃U，

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