發(fā)布時間：2019-04-27 19:22

【摘要】：目的觀察解毒活血配方顆粒沖服對經皮冠狀動脈介入術(PCI)患者的圍術期心肌損傷的影響。方法 160例接受PCI術的心絞痛患者隨機分為解毒活血組(n=84)和對照組(n=76),解毒活血組給予常規(guī)治療同時術前第7天給予解毒活血配方顆粒沖服,每日1劑。對照組給予基礎藥物治療。測定PCI術前及術后12 h、24 h的血清肌酸激酶同工酶(CK-MB)和肌鈣蛋白I(cTn I)濃度。結果解毒活血組PCI術后12 h、24 h cTn I和CK-MB水平均顯著低于對照組(P=0.0038,P=0.027 6;P=0.001 2,P=0.002 7)。解毒活血組患者術后cTn I和CK-MB升高大于正常值3倍者構成比均顯著低于對照組(P=0.008 2,P=0.007 6)。結論術前給予解毒活血配方顆粒對于PCI圍手術期病人的心肌損傷具有一定的保護作用。
[Abstract]:Objective to observe the effect of jiedu Huoxue recipe on perioperative myocardial injury in (PCI) patients undergoing percutaneous coronary intervention (PCI). Methods 160 patients with angina pectoris undergoing PCI were randomly divided into two groups: detoxification group (n = 84) and control group (n = 76). The patients in group A were treated with routine therapy and were given jiedu Huoxue formula granules once a day on the 7th day before operation. The control group was treated with basic drugs. Serum creatine kinase isoenzyme (CK-MB) and troponin I (cTn I) were measured before and 12 h and 24 h after PCI. Results the levels of 24 h cTn I and CK-MB in the detoxification and promoting blood circulation group at 12 h after PCI were significantly lower than those in the control group (P = 0.0038, P = 0.027 6, P = 0.001 2, P = 0.002 7). The ratio of cTn I and CK-MB increased more than 3 times of the normal value in the detoxification and activating blood circulation group after operation was significantly lower than that in the control group (P = 0.008 2, P < 0.007 6). Conclusion pre-operative administration of jiedu Huoxue formula granules has certain protective effect on myocardial injury in patients with PCI during perioperative period.
【作者單位】： 南京中醫(yī)藥大學附屬中西醫(yī)結合醫(yī)院心血管科;江蘇省中醫(yī)藥研究院;南京中醫(yī)藥大學;
【基金】：國家自然科學基金資助項目(No.81403386) 江蘇省自然科學基金資助項目(No.BK20161078) 中國中醫(yī)科學院江蘇分院資助項目(No.JSBY1316)~~
【分類號】：R541.4

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