【摘要】：目的:觀察麝香保心丸對冠心病心絞痛患者的療效及對遠期心臟事件的影響。方法:所選患者為我院門診或住院的冠心病心絞痛患者120例,隨機選擇對照組60例,給予常規(guī)冠心病二級預防治療(如阿司匹林、他汀類、β受體阻滯劑、血管緊張素轉(zhuǎn)換酶抑制劑等),隨機選擇同期觀察組60例,觀察組患者在常規(guī)治療基礎上口服麝香保心丸2粒/次,3次/日,觀察18個月。結(jié)果:觀察組與對照組治療18個月后比較血生化指標,如TC、TG、LDL-C、纖維蛋白原、血粘度、心肌總?cè)毖摵杉靶呐K相關事件(心絞痛發(fā)作次數(shù)、硝酸甘油消耗量、因心絞痛再住院率、心梗、心源性休克及猝死等)等均具有統(tǒng)計學意義(P0.05)。結(jié)論:麝香保心丸可有效降低冠心病心絞痛患者血液中TG、TC、LDL-C、纖維蛋白原及血粘度,還可降低患者的心肌細胞所有缺血的負荷,減少了冠心病心絞痛患者遠期(18個月)心臟相關事件的發(fā)生。
[Abstract]:Objective: to observe the effect of Shexiang Baoxin Pill on angina pectoris and long-term cardiac events. Methods: 120 patients with angina pectoris of coronary heart disease were selected in our hospital, and 60 patients in control group were randomly selected and treated with routine secondary prophylaxis of coronary heart disease (such as aspirin, statins, 尾 receptor blockers). Angiotensin converting enzyme inhibitor (angiotensin converting enzyme inhibitor etc.), 60 patients in the observation group were randomly selected. The patients in the observation group were given 2 tablets of Shexiang Baoxin pills on the basis of routine treatment, 3 times a day for 18 months. Results: the blood biochemical indexes such as TC,TG,LDL-C, fibrinogen, blood viscosity, total myocardial ischemic load and cardiac events (angina pectoris attack, nitroglycerin consumption) were compared between the observation group and the control group after 18 months of treatment. The readmission rate of angina pectoris, myocardial infarction, cardiogenic shock and sudden death were statistically significant (P0.05). Conclusion: Shexiang Baoxin pills can effectively reduce the TG,TC,LDL-C, fibrinogen and blood viscosity in patients with angina pectoris, and can also reduce the load of all myocardial ischemia in patients with angina pectoris. Decreased long-term (18 months) incidence of heart-related events in patients with coronary heart disease and angina pectoris.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R541.4

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