【摘要】：目的研究正常范圍內(nèi)不同濃度梯度的促甲狀腺激素(thyroid-stimulating hormone,TSH)對(duì)冠心病患者行經(jīng)皮冠狀動(dòng)脈介入術(shù)(percutaneous coronary interventions,PCI)預(yù)后的影響及其臨床意義。方法回顧性納入1 002例行PCI且TSH處于正常范圍內(nèi)(0.30~4.20μIU/m L)的冠心病患者,將受試者分為3組:TSH正常低值組(0.30~1.60μIU/m L,387例)、TSH正常中值組(1.61~2.90μIU/m L,413例)、TSH正常高值組(2.91~4.20μIU/m L,202例),隨訪時(shí)間1年,終點(diǎn)事件是全因死亡,并統(tǒng)計(jì)出血事件和再入院事件。結(jié)果正常低值組全因死亡事件6例,全因死亡率1.55%;正常中值組全因死亡事件8例,全因死亡率1.94%;正常高值組全因死亡事件10例,全因死亡率4.95%;各組之間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。正常低值組再出血事件13例,再出血率3.36%;正常中值組再出血事件14例,再出血率3.39%;正常高值組再出血事件16例,再出血率7.92%;各組之間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。正常低值組再入院事件38例,再入院率9.82%;正常中值組再入院事件27例,再入院率6.54%;正常高值組再入院事件15例,再入院率7.43%;各組之間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。Logistic回歸分析顯示正常高值的TSH(OR=1.48)是PCI術(shù)后全因死亡的危險(xiǎn)因素,同時(shí)正常高值的TSH(OR=1.47)是PCI術(shù)后出血的危險(xiǎn)因素。生存分析也進(jìn)一步證明正常高值的TSH是PCI術(shù)后全因死亡的危險(xiǎn)因素(P0.05)。結(jié)論 TSH水平越高,全因死亡事件、再出血事件的發(fā)生率越高;正常高值的TSH是經(jīng)皮冠狀動(dòng)脈介入治療的全因死亡和出血事件的危險(xiǎn)因素。
[Abstract]:Objective to study the effect of thyroid stimulating hormone (thyroid-stimulating hormone,TSH) on the prognosis of patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (percutaneous coronary interventions,PCI) and its clinical significance. Methods 1 002 coronary heart disease patients with PCI and TSH within normal range (0.30 鹵4.20 渭 IU/m / L) were retrospectively included. The subjects were divided into 3 groups: TSH normal low value group (0.30 鹵1.60 渭 IU/m L, n = 387). The median value of TSH group (1.61 鹵2.90 渭 IU/m / L) was 1.61 鹵2.90 渭 IU/m / L (2.91 鹵4.20 渭 IU/m / L), followed up for 1 year. The end point event was all cause of death, and the bleeding events and readmission events were counted. Results there were 6 cases of death events in the normal low value group, 1.55% of the total death rate, 8 cases of all the death events in the normal median group, 1.94% of the total death rate, 10 cases of all the death events in the normal high value group, and 4.95% of the total death rate. The difference between the groups was statistically significant (P0.05). In the normal low value group, there were 13 cases of rebleeding event, the rate of rebleeding was 3.36%, the mean group of normal value group was 14 cases of rebleeding event, the rate of rebleeding was 3.39 cases, the rebleeding rate of normal high value group was 7.92 2, and that of normal high value group was 7.92%. The difference between the groups was statistically significant (P0.05). In the normal low value group, the readmission rate was 9.82%, the normal median group was 27 cases, the readmission rate was 6.54, the normal high value group was 15 cases, the readmission rate was 7.43; There was no significant difference between the groups (P0.05). Logistic regression analysis showed that the normal high value of TSH (OR=1.48) is the risk factor of death after PCI, and the normal high value of TSH (OR=1.47) is the risk factor of PCI postoperative hemorrhage. Survival analysis further demonstrated that normal high TSH was a risk factor for all death after PCI (P0.05). Conclusion the higher the level of TSH, the higher the incidence of death events and rebleeding events, and the higher the normal value of TSH is the risk factor of death and bleeding events in percutaneous coronary intervention.
【作者單位】： 第三軍醫(yī)大學(xué)新橋醫(yī)院心血管內(nèi)科全軍心血管病研究所;
【分類號(hào)】：R541.4

【相似文獻(xiàn)】

相關(guān)期刊論文 前5條

1 李建軍;饒小胖;徐美華;;正常高值超敏促甲狀腺激素與血脂異常的相關(guān)性研究[J];中國(guó)循證心血管醫(yī)學(xué)雜志;2013年04期

2 金亞娟;;社區(qū)體檢對(duì)象血壓正常高值者的健康教育[J];中國(guó)衛(wèi)生標(biāo)準(zhǔn)管理;2014年12期

3 ;糖化血紅蛋白正常高值可預(yù)測(cè)2型糖尿病風(fēng)險(xiǎn)[J];中國(guó)社區(qū)醫(yī)師;2011年20期

4 周鴻雁;王欽國(guó);;肺結(jié)核31例誤疹肺癌分析[J];中國(guó)社區(qū)醫(yī)師(醫(yī)學(xué)專業(yè));2010年26期

5 ;[J];;年期

相關(guān)重要報(bào)紙文章 前3條

1 余光明;中年人怎樣對(duì)待“正常高值”血壓[N];家庭醫(yī)生報(bào);2007年

2 本報(bào)記者 李穎;盡量少做傷“心”事[N];科技日?qǐng)?bào);2013年

3 羅剛;新版高血壓防治指南解讀[N];健康報(bào);2006年

相關(guān)碩士學(xué)位論文 前1條

1 楊健姝;正常高值促甲狀腺激素與多囊卵巢綜合征的相關(guān)性研究[D];蘇州大學(xué);2014年

，

本文編號(hào)：2396965