【摘要】：目的探討研究老年骨質(zhì)疏松與頸動(dòng)脈硬化的相關(guān)性。方法將隨機(jī)抽取的236名60歲以上的體檢者作為研究對(duì)象,采用雙能X線骨密度儀測(cè)定腰椎(L_(1-4))及股骨頸、Word’s三角、大轉(zhuǎn)子的骨密度(bone mineral density,BMD)。采用高分辨率彩色超聲探查頸動(dòng)脈內(nèi)中膜厚度(intima-media thickness,IMT)及斑塊的情況。同時(shí)收集研究對(duì)象的基本資料,包括年齡、身高、體重、血鈣、血脂等生化結(jié)果。將入選對(duì)象分為骨質(zhì)疏松組和非骨質(zhì)疏松組,頸動(dòng)脈有斑塊組和頸動(dòng)脈無(wú)斑塊組。結(jié)果在骨質(zhì)疏松組(114例)中,存在內(nèi)膜增厚94例(82.46%),粥樣斑塊73例(64.04%),與非骨質(zhì)疏松組(122名)比較,骨質(zhì)疏松組在頸動(dòng)脈內(nèi)中膜增厚(IMT≥0.9 mm)及粥樣斑塊的發(fā)生率上均明顯升高(P0.05);IMT增厚及斑塊形成與骨量逐漸減少呈正相關(guān),IMT、年齡、體重指數(shù)(body mass index,BMI)與骨質(zhì)疏松發(fā)生顯著相關(guān)(P0.05);性別分組比較得出,女性骨質(zhì)疏松患者在頸動(dòng)脈斑塊中的發(fā)病率明顯高于男性和非骨質(zhì)疏松患者,其對(duì)比差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論老年骨質(zhì)疏松與動(dòng)脈硬化存在密切聯(lián)系;骨質(zhì)疏松人群較非骨質(zhì)疏松人群更易發(fā)生動(dòng)脈粥樣硬化病變,且女性骨質(zhì)疏松患者的頸動(dòng)脈硬化患病率明顯高于男性。
[Abstract]:Objective to study the correlation between senile osteoporosis and carotid atherosclerosis. Methods the bone mineral density (bone mineral density,BMD) of lumbar vertebrae (L1-4), femoral neck, Word's triangle and trochanter were measured by dual energy X-ray absorptiometry. Carotid intima media thickness (intima-media thickness,IMT) and plaque were examined by high resolution color ultrasound. At the same time, basic data were collected, including age, height, weight, blood calcium, blood lipid and other biochemical results. The subjects were divided into osteoporosis group and non-osteoporosis group, carotid plaque group and carotid artery without plaque group. Results there were 94 cases (82.46%) of intimal thickening and 73 cases (64.04%) of atherosclerotic plaques in the osteoporosis group (114 cases), which were compared with those in the non-osteoporosis group (122 cases). The incidence of carotid intima media thickening (IMT 鈮，

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