【摘要】：目的探討廣東地區(qū)漢族人群CTRP9基因多態(tài)性與冠心病遺傳易感的相關(guān)性。方法入選冠心病患者548例和對照個體862例,利用聚合酶鏈式反應(yīng)-連接酶檢測反應(yīng)(PCR-LDR)技術(shù)檢測CTRP9基因的兩個多態(tài)性位點rs6583、rs9553238的基因型,并采用Logistic回歸分析兩個多態(tài)位點和冠心病的易感性。結(jié)果 rs6583和rs9553238的等位基因、基因型頻率在廣東地區(qū)漢族人群的冠心病組和對照組分布中均無統(tǒng)計學差異(P0.05),構(gòu)建的顯性模型、隱性模型、加性模型在冠心病組和對照組中也無統(tǒng)計學差異(P0.05);CTRP9基因單體型(rs6583-rs9553238)在這兩組中仍未發(fā)現(xiàn)有統(tǒng)計學差異(P0.05)。結(jié)論 CTRP9基因rs6583和rs9553238多態(tài)位點與廣東地區(qū)漢族人群的冠心病遺傳易感無顯著相關(guān)性。
[Abstract]:Objective to investigate the association between CTRP9 gene polymorphism and genetic susceptibility to coronary heart disease (CHD) in Guangdong Han population. Methods A total of 548 patients with coronary heart disease and 862 controls were enrolled. Polymerase chain reaction-ligase assay (PCR-LDR) technique was used to detect the genotypes of rs6583,rs9553238 at two polymorphic sites of CTRP9 gene. Two polymorphic loci and susceptibility to coronary heart disease were analyzed by Logistic regression analysis. Results the alleles and genotype frequencies of rs6583 and rs9553238 were not significantly different in CHD group and control group in Guangdong Han population (P0.05). The dominant model and recessive model were constructed. There was no significant difference in the additive model between the coronary heart disease group and the control group (P0.05). CTRP9 haplotype (rs6583-rs9553238) was not found in the two groups (P0.05). Conclusion there is no significant correlation between the polymorphism of rs6583 and rs9553238 of CTRP9 gene and the genetic susceptibility to coronary heart disease in Guangdong Han population.
【作者單位】： 廣東醫(yī)科大學衰老研究所;廣東醫(yī)科大學廣東省醫(yī)學分子診斷重點實驗室;廣東醫(yī)科大學生物化學與分子生物學研究所;
【基金】：國家自然科學基金(81370456) 廣東省揚帆計劃培養(yǎng)高層次人才項目(4YF16006G) 東莞市社會科技發(fā)展項目(2015108101015,2013108101057)
【分類號】：R541.4

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