【摘要】：目的探討ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)行急診經(jīng)皮冠脈介入術(shù)(percutaneous coronary intervention,PCI)患者加用替格瑞洛治療的臨床效果及對患者心室重構(gòu)的影響。方法選取我院急診PCI手術(shù)治療的STEMI患者120例(2014年1月至2016年8月)進行回顧性分析,患者均急診PCI手術(shù),根據(jù)治療藥物分為兩組,60例患者術(shù)前及術(shù)后均給予替格瑞洛(替格瑞洛組)、60例患者術(shù)前及術(shù)后均給予氯吡格雷(氯吡格雷組),對比兩組患者術(shù)后心室重構(gòu)指標、心電圖等指標。結(jié)果術(shù)后12周,替格瑞洛組LVEDd(49.1±5.4)mm、LVESD(40.6±4.6)mm、LVMI(112.8±11.0)g/m~2、LVMW(140.7±18.5)g低于氯吡格雷組患者LVEDd(53.1±4.6)mm、LVESD(43.9±4.7)mm、LVMI(118.2±9.4)g/m2、LVMW(153.0±21.3)g(t=4.638、t=3.887、t=2.891、t=2.198,P均0.05),兩組患者的LVEF值差異無統(tǒng)計學(xué)意義(t=1.064,P0.05);術(shù)后12周,替格瑞洛組Tp-e(114.2±12.7)ms、Tp-e/QTc(0.20±0.05)低于氯吡格雷組患者Tp-e(120.6±13.9)ms、Tp-e/QTc(0.25±0.07)(t=2.633、t=4.502,P0.05);替格瑞洛組的不良心血管事件發(fā)生率6.67%與氯吡格雷組的13.33%比較,差異無統(tǒng)計學(xué)意義(χ2=1.481,P0.05)。討論STEMI行PCI患者加用替格瑞洛治療能有效減輕心室重構(gòu),改善心電圖指標。
[Abstract]:Objective to investigate the effect of tigrilol on ventricular remodeling in patients with ST segment elevation myocardial infarction (ST-segment elevation myocardial infarction,STEMI) undergoing emergency percutaneous coronary intervention (percutaneous coronary intervention,PCI). Methods one hundred and twenty patients with STEMI underwent emergency PCI operation in our hospital from January 2014 to August 2016 were retrospectively analyzed. According to the therapeutic drugs, 60 patients were divided into two groups: before and after operation, 60 patients were given clopidogrel (clopidogrel group) before and after operation, and the indexes of ventricular remodeling and electrocardiogram were compared. 緇撴灉鏈悗12鍛，

本文編號：2211835