控制不同INR對(duì)老年穩(wěn)定性冠心病合并房顫患者的臨床觀察
發(fā)布時(shí)間：2018-08-27 18:37
【摘要】：目的觀察老年穩(wěn)定性冠心病合并非瓣膜性心房顫動(dòng)患者在使用華法林抗凝治療過程中控制不同血漿凝血酶原時(shí)間國際標(biāo)準(zhǔn)化比值(INR)的預(yù)后和安全性影響。方法選擇老年穩(wěn)定性冠心病合并非瓣膜性心房顫動(dòng)患者81例,隨機(jī)分為A組(低抗凝組)41例,調(diào)整INR 1.5~2.0;B組(常規(guī)抗凝組)40例,調(diào)整INR 2.0~3.0。隨訪時(shí)間為1年,比較兩組主要終點(diǎn)事件及安全性終點(diǎn)情況。結(jié)果治療1年后,比較兩組INR和華法林的劑量,A組顯著低于B組,差異具有統(tǒng)計(jì)學(xué)意義(P0.01);治療結(jié)束時(shí)兩組終點(diǎn)事件比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者都沒有致命性出血事件發(fā)生,出血事件比例B組高于A組,差異具有統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論華法林低強(qiáng)度抗凝可預(yù)防老年穩(wěn)定性冠心病合半非瓣膜性心房顫動(dòng)患者缺血性腦卒中等血栓事件發(fā)生。
[Abstract]:Objective to investigate the prognostic and safety effects of different plasma prothrombin time ratios (INR) in elderly patients with stable coronary heart disease (CHD) complicated with non-valvular atrial fibrillation (NAF) during warfarin anticoagulant therapy. Methods Eighty-one elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation were randomly divided into three groups: group A (low anticoagulant group, n = 41), group B (conventional anticoagulant group, n = 40, adjusted INR 1.5 + 2.0) and INR 2.0, 3.0, respectively. The follow-up time was 1 year to compare the main endpoint events and safety endpoints between the two groups. Results after one year of treatment, the dose of INR and warfarin in group A was significantly lower than that in group B (P0.01). There was no significant difference between the two groups (P0.05). There were no fatal bleeding events in the two groups. The proportion of bleeding events in group B was higher than that in group A. the difference was statistically significant (P0.01). Conclusion warfarin low-intensity anticoagulation can prevent ischemic stroke in elderly patients with stable coronary heart disease and semi-non-valvular atrial fibrillation.
【作者單位】： 重慶三峽醫(yī)藥高等�？茖W(xué)校附屬醫(yī)院心內(nèi)科;
【分類號(hào)】：R541.4;R541.75
本文編號(hào)：2208103
[Abstract]:Objective to investigate the prognostic and safety effects of different plasma prothrombin time ratios (INR) in elderly patients with stable coronary heart disease (CHD) complicated with non-valvular atrial fibrillation (NAF) during warfarin anticoagulant therapy. Methods Eighty-one elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation were randomly divided into three groups: group A (low anticoagulant group, n = 41), group B (conventional anticoagulant group, n = 40, adjusted INR 1.5 + 2.0) and INR 2.0, 3.0, respectively. The follow-up time was 1 year to compare the main endpoint events and safety endpoints between the two groups. Results after one year of treatment, the dose of INR and warfarin in group A was significantly lower than that in group B (P0.01). There was no significant difference between the two groups (P0.05). There were no fatal bleeding events in the two groups. The proportion of bleeding events in group B was higher than that in group A. the difference was statistically significant (P0.01). Conclusion warfarin low-intensity anticoagulation can prevent ischemic stroke in elderly patients with stable coronary heart disease and semi-non-valvular atrial fibrillation.
【作者單位】： 重慶三峽醫(yī)藥高等�？茖W(xué)校附屬醫(yī)院心內(nèi)科;
【分類號(hào)】：R541.4;R541.75
【相似文獻(xiàn)】
相關(guān)期刊論文 前2條
1 ;國際標(biāo)準(zhǔn)化比值INR究竟要調(diào)整在哪個(gè)范圍?[J];心血管病防治知識(shí);2009年08期
2 楊帆;杜昕;劉曉惠;;華法林應(yīng)用初期INR變化的分析[J];廣西醫(yī)學(xué);2005年12期
相關(guān)碩士學(xué)位論文 前4條
1 郭會(huì)軍;華法林初始劑量與INR達(dá)標(biāo)率的研究[D];河北醫(yī)科大學(xué);2015年
2 李可莉;不同年齡對(duì)房顫患者口服華法林后INR達(dá)標(biāo)劑量和時(shí)間的影響[D];河北醫(yī)科大學(xué);2014年
3 劉艷霞;非瓣膜病房顫或房撲患者應(yīng)用不同起始劑量華法林對(duì)INR達(dá)標(biāo)速度的影響[D];大連醫(yī)科大學(xué);2009年
4 董自雙;基于排除INR的終末期肝病模型評(píng)分評(píng)估心力衰竭預(yù)后[D];吉林大學(xué);2015年
，本文編號(hào)：2208103
本文鏈接：http://sikaile.net/yixuelunwen/xxg/2208103.html
最近更新
教材專著
