冠心病患者半乳糖凝集素-3與冠脈病變程度及預(yù)后的相關(guān)性研究
[Abstract]:Objective: to detect the level of serum galactose agglutinin 3 (Galectin-3) in patients with coronary heart disease (CHD) and its correlation with Gensini integral type B brain natriuretic peptide (BNP). The relationship between serum Galectin-3 level and the severity and prognosis of coronary artery disease (CHD) was investigated by observing the relationship between serum Galectin-3 level and the occurrence of main cardiovascular events (MACE) in patients with coronary heart disease (CHD). Methods: from July 2013 to March 2014, patients with coronary heart disease (CAD) were diagnosed as coronary heart disease (CHD) according to clinical manifestation, electrocardiogram (ECG), myocardial enzyme or coronary angiography (CAG). Forty patients with stable angina pectoris (SA) were randomly selected as group A and 40 patients with unstable angina pectoris (UA) as group B and 40 patients with acute myocardial infarction (AMI) as group C. A total of 40 healthy subjects were collected from our physical examination center as the normal control group (group D). Enzyme linked immunosorbent assay (ELISA) was used to detect the level of serum Galectin-3 and chemiluminescence to detect the level of BNP. The degree of coronary stenosis was estimated by Gensini integral system. 120 patients with CAD were followed up for 1 year. Results 1. The level of serum Galectin-3 in patients with CAD was higher than that in normal controls, and the level of serum Galectin-3 in group C was higher than that in group B (P < 0. 197). The level of serum Galectin-3 in group B was higher than that in group A (P < 0. 197). 2. Spearman correlation analysis showed that Galectin-3 was positively correlated with Gensini score. 15 patients were followed up for 1 year. Compared with the non-adverse cardiovascular events group, the serum Galectin-3 level of the patients with cardiovascular adverse events was significantly higher than that of the non-adverse cardiovascular events group (p0.05) 4. Multivariate Logistic regression analysis showed that the level of serum Galectin-3 (OR 1.157, CI: 1.047-1.279 / p0.01) was positively correlated with the poor prognosis in patients with coronary heart disease (OR 1.010 CI: 1.000-1.034 P 0.028). Conclusion 1. The serum Galectin-3 level in patients with coronary heart disease may be related to plaque instability. 2. 2. The level of serum Galectin-3 was positively correlated with the severity of coronary artery disease. 3. Galectin-3 may promote the occurrence, development and ventricular remodeling of coronary atherosclerosis. CAD patients with high serum Galectin-3 level may have poor prognosis.
【學(xué)位授予單位】:濱州醫(yī)學(xué)院
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2015
【分類號(hào)】:R541.4
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