急性冠脈綜合征PCI后取消負(fù)荷量靜注僅小劑量應(yīng)用替羅非班的研究
發(fā)布時(shí)間：2018-08-14 14:41
【摘要】：目的比較急性冠脈綜合征行急診PCI后,取消負(fù)荷量而直接靜脈小劑量維持應(yīng)用替羅非班與常規(guī)應(yīng)用是否具有相同的降低心血管事件的發(fā)生率的作用,且減少出血并發(fā)癥的發(fā)生。方法選擇行急診PCI術(shù)且術(shù)后應(yīng)用替羅非班的急性冠脈綜合征的病人,分為常規(guī)劑量與小劑量組;病人術(shù)后按常規(guī)劑量泵入替羅非班(首先以10μg/kg靜脈1-3 min內(nèi)推注,繼之以0.15μg/(kg·min)維持靜脈泵入36 h);小劑量組未給予負(fù)荷劑量直接靜脈小劑量替羅非班泵入,以0.15μg/(kg·min)維持靜脈泵入36 h;觀察兩組患者院內(nèi)死亡率、再發(fā)心肌梗死率、出血率。結(jié)果兩組院內(nèi)心源性死亡率無顯著差異(P=0.492);院內(nèi)再發(fā)梗死率無顯著差異(P=0.721)。小劑量組輕度出血率明顯低于常規(guī)劑量組(P=0.001),重度出血率明顯低于常規(guī)劑量組(P=0.035)。結(jié)論急性冠脈綜合征行急診PCI術(shù),不給予負(fù)荷量而直接靜脈小劑量維持應(yīng)用替羅非班與常規(guī)應(yīng)用替羅非班對病人降低心血管事件發(fā)生率效果相當(dāng),且明顯降低出血風(fēng)險(xiǎn)。
[Abstract]:Objective to compare whether tirofiban has the same effect on reducing the incidence of cardiovascular events and reducing the incidence of hemorrhage complications after emergency PCI in patients with acute coronary syndrome (ACS). Methods patients with acute coronary syndrome (ACS) who underwent emergency PCI and were treated with tirofiban were divided into two groups: routine and low dose groups, and were pumped into tirofiban (10 渭 g/kg intravenous 1-3 min) after operation. Then, 0.15 渭 g / (kg min) was injected into the low dose group for 36 h); without loading dose, and 0.15 渭 g / (kg min) for 36 h. The hospital mortality, recurrent myocardial infarction rate and bleeding rate of the two groups were observed. Results there was no significant difference in cardiac mortality between the two groups (P0. 492), but there was no significant difference in the rate of recurrent infarction in the hospital (P0. 721). The rate of mild hemorrhage in the low dose group was significantly lower than that in the conventional dose group (P0. 001), and the severe bleeding rate in the low dose group was significantly lower than that in the conventional dose group (P0. 035). Conclusion PCI is effective in reducing the incidence of cardiovascular events and reducing the risk of hemorrhage in patients with acute coronary syndrome treated with direct intravenous low-dose tirofiban without loading and routine use of tirofiban.
【作者單位】： 吉林市中心醫(yī)院心臟中心;吉林市新農(nóng)合管理中心;Rutgers
【分類號(hào)】：R541.4
[Abstract]:Objective to compare whether tirofiban has the same effect on reducing the incidence of cardiovascular events and reducing the incidence of hemorrhage complications after emergency PCI in patients with acute coronary syndrome (ACS). Methods patients with acute coronary syndrome (ACS) who underwent emergency PCI and were treated with tirofiban were divided into two groups: routine and low dose groups, and were pumped into tirofiban (10 渭 g/kg intravenous 1-3 min) after operation. Then, 0.15 渭 g / (kg min) was injected into the low dose group for 36 h); without loading dose, and 0.15 渭 g / (kg min) for 36 h. The hospital mortality, recurrent myocardial infarction rate and bleeding rate of the two groups were observed. Results there was no significant difference in cardiac mortality between the two groups (P0. 492), but there was no significant difference in the rate of recurrent infarction in the hospital (P0. 721). The rate of mild hemorrhage in the low dose group was significantly lower than that in the conventional dose group (P0. 001), and the severe bleeding rate in the low dose group was significantly lower than that in the conventional dose group (P0. 035). Conclusion PCI is effective in reducing the incidence of cardiovascular events and reducing the risk of hemorrhage in patients with acute coronary syndrome treated with direct intravenous low-dose tirofiban without loading and routine use of tirofiban.
【作者單位】： 吉林市中心醫(yī)院心臟中心;吉林市新農(nóng)合管理中心;Rutgers
【分類號(hào)】：R541.4
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1 怯紅曉;董平栓;;替羅非班在老年急性冠狀動(dòng)脈綜合征中的應(yīng)用[J];中國心血管病研究;2008年12期
2 申紅遠(yuǎn);梁偉;湯U，
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